Results 101 to 110 of about 57,879 (291)
The development and use of strategic business performance improvement frameworks for rapid prototyping and tooling : executive summary [PDF]
Increasing global competition within industry has forced businesses to respond by reducing costs and product development lead times in order to survive.
Halliday, Ian
core
Systems Methodology for Strategic Decision-making in Complex Healthcare System
, 2017 Systems methodology as a support for strategic decision-making will be discussed in the paper. A society will be presented as a complex system, which is comprised of many smaller, complex systems as its component parts.
Jere Jakulin, Tadeja
core +1 more source
Requirements Engineering Model: Role Based Goal Oriented Model
MATEC Web of Conferences, 2016 Requirements engineering approach through intentional perspective is one of the arguments that appear in the field of requirement engineering. That approach can explain the characteristics of the behavior of an actor.
Sandfreni, Surendro Ir. Kridanto
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Understanding the Strategic Actor Diagram: an Exercise of Meta Modeling
, 2008 i-star (i*) modeling uses the actor concept to ground the intentions of a given Universe of Discourse. Our work contributes to the understanding of the actor concept as used in i*.
Sampaio Prado +9 more
core
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Evaluating the adoption of strategic information systems planning (SISP) in global organisations
, 2010 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.In a comprehensive review of literature on the strategic adoption of information systems (IS), various approaches to strategic IS adoption were unable to ...
Basahel, Abdullah M
core
The political economy of opencast mining in Scotland and the north east of England [PDF]
, 1993 This is an interdisciplinary, descriptive, empirical study and analysis of the use of opencast mining in a complex process of commercialisation of the coal industry, its impact upon the environment and communities.
Ellison, J.M, Ellison, James M.
core