Results 51 to 60 of about 57,879 (291)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Strategic diagram of Tardivo Algorithm.
, 2015 The diagram indicates the parameters significantly important to evaluate diabetic foot and obtain the score values.
Fernando Adami (784200) +4 more
core +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Model of the control system of national economic security
MATEC Web of Conferences, 2018 The article outlines a diagnostic model for controlling the national economic security. The diagnostic approach was characterized as the tool for assessing economic security and availability of means. The author described dynamic CLD (Casual Loop Diagram)
Olejniczak Jarosław
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Strategy for Biodiversity Conservation Efforts in Wasur National Park of Merauke in Merauke Regency
E3S Web of Conferences, 2018 Development of Wasur National Park can drive the economy, improve local and national images, improve public welfare through purchase of local product, open jobs and increase regional income. Tourism sector will be an effective means.
W Ririhena Samel +2 more
doaj +1 more source
International Journal of Business and Management, 2013 American University of Nigeria (AUN), was established in 2005 and has emerged as Nigeria’s most preferred university. Located in Yola, Adamawa State, North-eastern Nigeria, the university was conceived in response to the need for a world-class university in sub-Saharan Africa.
Apollos Bitrus Goyol +1 more
openaire +2 more sources
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source