Results 61 to 70 of about 57,879 (291)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Strategic diagram metrics and micro cluster classification.

Strategic diagram metrics and micro cluster classification.
Nelson Alfonso Gómez-Cruz (17879700), David Anzola (17879703), Aglaya Batz Liñeiro (17879706)   +2 more
core   +1 more source

e‐Maintenance Framework for Strategic Asset Management in Tertiary Institutions [PDF]

, 2019
Tertiary institutions require buildings such as its senate building, classrooms, laboratories, administrative rooms, hostels and other offices in order to function.
Afolabi, A.O., Eshofonie, E. E., Akinbo, Faith, Afolabi, I. T.   +3 more
core   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Co-word analysis for the non-scientific information example of Reuters Business Briefings

Data Science Journal, 2006
Co-word analysis is based on a sociological theory developed by the CSI and the SERPIA (Callon, Courtial, Turner, 1991) in the mid eighties. This method, originally dedicated to scientific fields, measures the association strength between terms in ...
B Delecroix, R Eppstein
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Do structured methods help eco-innovation: An evaluation of the product ideas tree diagram

, 2001
This paper reports on the first test of the Product Ideas Tree diagram (PIT): a structured method aimed to help Eco-innovation. The PIT diagram structures ideas output from chaotic idea generating sessions.
Harrison, D., Stanton, NA, Stanton, N.A., Jones, E, Harrison, DJ, Jones, E.   +5 more
core   +1 more source

Determinants Generating General Purpose Technologies in Economic Systems: A New Method of Analysis and Economic Implications

JOIV: International Journal on Informatics Visualization
This research proposes using the fishbone diagram, a visualization tool for constructing a comprehensive theoretical framework to analyze the sources of innovation.
Bilal Kargı, Mario Coccia, Bekir Cihan Uçkaç, - Rasyidah   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source