Results 71 to 80 of about 812,510 (332)

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

The assessment of the environmental effects in the Strategic Environmental Assessment process: a methodological approach

Aestimum
Strategic Environmental Assessment (SEA) is a well-established procedure to support Decision Makers (DMs) in considering and evaluating the effects of Policies, Plans, and Programs (PPPs) on the environment, along with social and economic considerations,
Antonio Boggia, Arianna Tiralti, Lucia Rocchi, Luisa Paolotti   +3 more
doaj   +1 more source

Strategic environmental assessment in action [PDF]

Journal of Integrative Environmental Sciences, 2011
Strategic environmental assessment in action, by Riki Therivel, London, UK, Earthscan, 2010, 366 pp., £29.95 (paperback), ISBN 978-1-84971-065-7 Strategic environmental assessment (SEA) is a proces...
openaire   +1 more source

The Irish Rural Environmental Protection Scheme and lack of Strategic Environmental Assessment [PDF]

, 2010
working paperProposals specifically aimed at delivering environmental benefits are often exempt from assessment, despite evidence that they can be poorly thought-through and sometimes counterproductive. This is doubly true of agri-environmental schemes
Fry, John, Whelan, Jackie
core  

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Consideration of urban green space in impact assessments for health [PDF]

, 2018
This paper explores how health aspects connected with the planning of urban green space are currently supported through two types of impact assessments: health impact assessment (HIA) and environmental assessment, including strategic environmental ...
[IAEA] International Atomic Energy Agency, [WHO] World Health Organization, Carmichael L, Cave B, de Vries S, Fischer TB, Fischer TB, Fischer TB, Hanusch M, Julia Nowacki, Morris N, O’Mullane M, Peter Fawcett, Rebmann A, Samuel Hayes, Sarah Clement, Thomas B. Fischer, Urmila Jha-Thakur, Zupancic T   +18 more
core   +3 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Energy [PDF]

, 2016
The impact of energy policy measures has been assessed with various appraisal and evaluation tools since the 1960s. Decision analysis, environmental impact assessment and strategic environmental assessment are all notable examples of progenitors of ...
Torriti, Jacopo
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source