Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Strategic Planning and Public Opinion Survey [PDF]
Strategic Planning is a creative, practical planning process for community change. Community Strategic Planning produces a visionary statement of what the community wants to be 10 to 20 years in the future.
Natasa Urbancikova, Oto Hudec
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Private Equity Partnerships with Orthopedic Groups: 2022 Trends and Strategic Insights for 2023 Including Insights from Special Feature: Survey of Orthopedic Surgeons on “Life After Closing” in Private Equity Deals [PDF]
, 2023 Gary W Herschman +2 more
openalex +1 more source
Patterns of competition and strategic groups in the special cheese industry in Brazil [PDF]
The aim of this study is to identify the competition pattern in the Brazilian special cheese industry, and the strategic groups of this market. Based mainly on the Industrial Organization Theory, a qualitative study was conducted, supported by primary ...
Castro, Cleber Carvalho de +1 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Who Does and Who Does Not Engage in Strategic Litigation in European Law?
German Law JournalBoth European Union law and the European Convention on Human Rights offer an opportunity structure for a broad array of interests to pursue their objectives through strategic litigation.
Andreas Hofmann
doaj +1 more source
Strategic manipulation in group decisions with pairwise comparisons: A game theoretical perspective
, 2022 Yasuo Sasaki
openalex +1 more source
Strategy and small firm performance [PDF]
The objective of this study is to contribute to the debate on the relationship between strategy and firm performance, especially for SMEs. The research questions are: Can different strategic groups of SMEs be identified and to what extent does the ...
Petra Gibcus, Ron Kemp
core