Results 61 to 70 of about 240,760 (262)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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Business Models Peculiarities and their Impact on Corporations’ Development
Управленческие науки, 2016 The article analyzes the business models of transnational metallurgical corporations. The peculiarities of business models and their impact on the efficiency and sustainable development are revealed.
V. V. Smirnov
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
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Strategic prospective in knowledgemanagement: A proposal for research groups in Colombia
Revista Investigación & Desarrollo, 2013 Este artículo de reflexión trata de relacionar los conceptos de prospec- tiva, con la gestión estratégica del conocimiento, y su papel dentro de los grupos de investigación (GRIN) de las universidades colombianas.
Leonardo Pineda Serna
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
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Boards' strategic involvement models: Past, present, and future [PDF]
Strategic ManagementBackground: The research on boards' strategic involvement has increased dramatically in the last few decades due to the need for improving boards' strategic effectiveness as a mechanism for improving organizational performance.
Bozhinovska Tihona, Eftimov Ljupcho
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
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Вестник Северо-Кавказского федерального университета, 2022 It defines three groups of parameters that must be considered in the development of strategic programs of development ofmineral resources complex of local importance.
lexey Cherepovitsyn, Galina Peshkova
doaj
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
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