Results 81 to 90 of about 13,620 (256)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Kenya’s Strategic Health Purchasing Progress Matrix

Countries, including Kenya, have committed to achieve Universal Health coverage (UHC) and are increasingly reforming their health systems to achieve this goal.
Kabia, Evelyn, Munge, Kenneth, Kazungu, Jacob, Barasa, Edwine   +3 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Counter-verification in performance-based financing: key insights from the Côte d’Ivoire experience

Global Health Action
Background Performance-based financing (PBF) is a key health financing reform in many sub-Saharan African countries, with verification being a critical component.
Joël Arthur Kiendrébéogo, Kouadjo San Boris Bediakon, Jean-Pierre Tsafack, Marin Passerat De Silans, Robert Yao Kouakou, Clovis Kouassi Konan, Sosthène Dougrou, Xavier Lannuzel, Serge Mayaka Manitu   +8 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Purchasing Organization and Design: A Literature Review [PDF]

This paper presents the results of a comprehensive literature review of the organization of purchasing covering the period from 1967 to 2009. The review provides a structured overview of prior research topics and findings and identifies gaps in the ...
Christoph Glock, Simon Hochrein
core  

A critical analysis of health care purchasing arrangements in Kenya: A case study of the county departments of health

, 2018
BACKGROUND:Purchasing in health care financing refers to the transfer of pooled funds to health care providers for the provision of health care services.
Mbau, Rahab, Edwine Barasa, Rahab Mbau, Mulupi, Stephen, Nguhiu, Peter K, Peter K. Nguhiu, Munge, Kenneth, Stephen Mulupi, Kenneth Munge, Chuma, Jane, Jane Chuma, Barasa, Edwine   +11 more
core   +1 more source

The comparative study of strategic purchasing of health services in selected countries: A Review Study

Bali Medical Journal, 2018
Introduction: strategic purchasing is the constant search for achieving the best method through deciding on what to purchase, how to do it, and choosing service providers in a way that maximizes the health system performance to the desired level. In other words, strategic purchasing is defined as interventions that enhance system's accountability and ...
Abedi, Ghasem, Shojaee, Jalil, Bastani, Peivand, Kabir, Mohammad Javad, Yazdani, Jamshid   +4 more
openaire   +3 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source