Results 101 to 110 of about 13,620 (256)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Designing a pragmatic model for strategic purchasing of health services in health insurance companies: The feasible pivot of strategic purchasing in a developing country

, 2019
Purpose: The purpose of this paper is to identify the most important factors for strategic purchasing of health services in the health sector by the Iran Health Insurance Company and to provide an applicable model for other similar organizations in ...
Bastani, P., Tahernezhad, A., Teymourzadeh, E., Panahi, S., Bahadori, M., Hakimzadeh, S.M., Rezapour, A.   +6 more
core  

Key policies and challenges of the strategic purchasing in the health system of Colombia

, 2019
Colombia has a multiple purchaser market organised across different administrative levels, which often results in an overlapping functions and roles among ministries, mandatory health insurances schemes and private bodies. Overall topics 1. Methodology of the assessment. 2.
Rivillas, Juan Carlos, Lopez-Echeverri, Daniela, Henao, Ana Cristina   +2 more
openaire   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Library purchasing consortia in the UK: activity, benefits and good practice.

, 1999
Following a brief introduction in Section 1, Section 2 sets out the operational context of library purchasing consortia. A range of key factors have shaped recent developments in the four LIS sectors under consideration (FE, HE, health and public ...
Ball, David, Pye, Jo
core  

Adjustments in purchasing arrangements to support the COVID-19 health sector response:Evidence from eight middle-income countries

The COVID-19 pandemic has triggered several changes in countries' health purchasing arrangements to accompany the adjustments in service delivery in order to meet the urgent and additional demands for COVID-19 related services.
Rivillas, Juan Carlos, Gong, Estelle, Onwujekwe, Obinna, Nketiah-Amponsah, Edward, Parmar, Divya, Wee Co, Pura Angela, Domingo, Albert Francis, Obikeze, Obioma, Vîlcu, Ileana, Chen, Dorothee, Nkangu, Miriam, Parmar, Divya; id_orcid, Abuosi, Aaron Asibi, Tapkigen, Janet, Goroshko, Alona, Co, Pura Angela Wee, Mathauer, Inke, Wang, Huihui, Bloom, Danielle, Dkhimi, Fahdi, Lylozian, Hratchia, Chukwuma, Adanna, Pattnaik, Anooj, Doroshenko, Olena, de Claro, Vergil, Comsa, Radu   +25 more
core   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Factors Required to Develop Strategic Purchasing for Diagnostic Imaging Services: An Expert Opinion

BACKGROUND: In recent decades, healthcare purchasing has been continuously searching for new approaches to improve performance. The pressure of expensive services resulting from more advanced health technology has increased the necessity of these changes.
Bastani, P., Jabbari, A., Shaarbafchizadeh, N., Soltan-Tajian, A.   +3 more
core   +1 more source