Results 1 to 10 of about 21,663 (162)

SPARC Overexpression Promotes Liver Cancer Cell Proliferation and Tumor Growth

Frontiers in Molecular Biosciences, 2021
Background: Secreted protein acidic and rich in cysteine (SPARC) plays an important role in cancer development. The roles of SPARC in the liver hepatocellular carcinoma (LIHC) are unclear.Methods: GEPIA2 and UALCAN were used to analyze the SPARC mRNA ...
Zhao-Wei Gao, Ting He, Xia-Nan Wu
exaly   +3 more sources

SPARC upregulation mediates podocyte injury in Alport syndrome mice [PDF]

BMC Nephrology
Background Alport syndrome (AS) is a hereditary kidney disease characterized by hematuria, proteinuria, and progressive kidney failure. Podocyte injury is an important feature of AS, but the underlying molecular mechanisms remain incompletely understood.
Dongxuan Chi, Hongyuan Chu, Jing Nie, Yanqin Zhang, Fang Wang, Jie Ding   +5 more
doaj   +2 more sources

SPARC modulates macrophage-like phenotype transformation in VSMCs and triggers a vicious cycle [PDF]

Frontiers in Cell and Developmental Biology
Intracranial aneurysms (IAs) are characterized by abnormal cerebral artery dilations and pose significant risks due to their potential for rupture, leading to subarachnoid hemorrhage.
Gengfan Ye, Hongcai Wang, Kuan Feng, Shiwei Li, Xuebin Wen, Zhenqiang Li, Wei Chen, Maosong Chen   +7 more
doaj   +2 more sources

An unsaturated soil mechanics approach for performance-based intelligent compaction [PDF]

E3S Web of Conferences, 2023
Intelligent compaction involves using instrumented rollers to provide real-time monitoring of the compacted ground using sensors such as accelerometers and GPS.
Chen Liuxin, Ghorbani Javad, Tophel Amir, Kodikara Jayantha   +3 more
doaj   +1 more source

Effect of aerobic and resistance training on secreted protein acidic rich in cysteine, decorin, and myonectin muscle genes expression in rats fed with a high-fat diet [PDF]

Journal of Shahrekord University of Medical Sciences, 2023
Background and aims: Fatty diet can affect the expression of myokines. Thus, the aim of this study was to evaluate the effect of aerobic and resistance training secreted protein acidic rich in cysteine (SPARC), decorin (DCN), and myonectin muscle gene ...
Mostafa Babaeinejad, Hasan Matinhomaee, Hoseyn Fatolahi   +2 more
doaj   +1 more source

An Intelligent Compaction Analyzer: A Versatile Platform for Real-Time Recording, Monitoring, and Analyzing of Road Material Compaction

Sensors, 2023
Intelligent compaction (IC) is a technology that uses non-contact sensors to monitor and record the compaction level of geomaterials in real-time during road construction.
Rajitha Ranasinghe, Arooran Sounthararajah, Jayantha Kodikara   +2 more
doaj   +1 more source

Balancing revenue generation with capacity generation: case distribution, financial impact and hospital capacity changes from cancelling or resuming elective surgeries in the US during COVID-19

BMC Health Services Research, 2020
Background To increase bed capacity and resources, hospitals have postponed elective surgeries, although the financial impact of this decision is unknown.
Joseph E. Tonna, Heidi A. Hanson, Jessica N. Cohan, Marta L. McCrum, Joshua J. Horns, Benjamin S. Brooke, Rupam Das, Brenna C. Kelly, Alexander John Campbell, James Hotaling   +9 more
doaj   +1 more source

Open access and author rights: questioning Harvard’s open access policy

Insights: The UKSG Journal, 2020
Harvard’s open access (OA) policy, which has become a template for many institutional OA policies, intrinsically undermines the rights of scholars, researchers, authors and university staff, and it adulterates a principal tenet of open access, namely ...
Patrick H. Alexander
doaj   +1 more source

Secreted Protein Acidic and Rich in Cysteine (Sparc) KO Leads to an Accelerated Ageing Phenotype Which Is Improved by Exercise Whereas SPARC Overexpression Mimics Exercise Effects in Mice

Metabolites, 2022
Secreted protein acidic and rich in cysteine (SPARC) is a matricellular glycoprotein implicated in various functions, including metabolism, tissue regeneration, and functional homeostasis. SPARC/Sparc declines with ageing but increases with exercise.
Abdelaziz Ghanemi, Aicha Melouane, Mayumi Yoshioka, Jonny St-Amand   +3 more
doaj   +1 more source

Hypoxic regulation of the expression of anti-angiogenic genes in U87 glioma cells with loss of function of ern1 signaling enzyme

Біологічні студії, 2012
The angiogenesis is an important component of tumor growth and tightly associated with hypoxia. The expression level of genes related to regulation of angiogenesis (BAI2, SPARC, TIMP1, TIMP2, TIMP3, TIMP4, THBS1, THBS2, ADAMTS5 and FGF2) in glioma ...
K. I. Kubaichuk, D. O. Minchenko, S. V. Danilovskyi, A. Y. Kuznetsova, A. K. Jassim, O. H. Minchenko   +5 more
doaj   +1 more source