Results 31 to 40 of about 22,630 (210)

Aberrant Promoter Methylation of Sparc in Ovarian Cancer

Neoplasia: An International Journal for Oncology Research, 2009
Epigenetic silencing of tumor suppressor genes is a new focus of investigation in the generation and proliferation of carcinomas. Secreted protein acidic and rich in cysteine (SPARC) is reportedly detrimental to the growth of ovarian cancer cells and has
Matthew J. Socha, Neveen Said, Yanshan Dai, Joseph Kwong, Preetha Ramalingam, Vuong Trieu, Neil Desai, Samuel C. Mok, Kouros Motamed   +8 more
doaj   +1 more source

Defect‐Mediated Inelastic Light Scattering by Infrared Phonons in Hexagonal Boron Nitride

Advanced Functional Materials, EarlyView.
Optically active defects in hexagonal boron nitride enable inelastic stimulated light scattering mediated by infrared‐active phonons, relaxing conventional Raman selection rules. Defect engineering enhances the Stokes‐conversion process and activates both TO‐ and LO‐phonon scattering channels.
Prabhdeep Singh, Bharti Garg, Maximilian Black, Masoud Taleb, Nahid Talebi   +4 more
wiley   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

A SPARC test of the central-body statistical-mechanics disk model: downbending successes, physical vetting, and mass-to-light ratio systematics

Open Astronomy
We test Kang’s (2024) central-body statistical-mechanics disk model against SPARC 3.6 μm profiles using the ordinary-differential-equation system defined by that paper’s Equation (28).
Kang Dong-Biao
doaj   +1 more source

Condition‐Associated Pattern Extraction and Recovery From Multi‐Condition Single‐Cell RNA‐seq Data With CAPER

Advanced Science, EarlyView.
Decoupling biological signals from unwanted variation in multi‑condition single‑cell RNA sequencing data remains challenging. CAPER disentangles condition‑associated biological effects from sample heterogeneity through matrix factorization, producing interpretable latent factors and a batch‑corrected expression matrix.
Ye Li, Jin Ning, An Wang, Minxi Shi, Yuanze Chen, Guoliang Liu, Shiquan Sun   +6 more
wiley   +1 more source

A Commentary on the SPARC Study

Journal of the American College of Cardiology, 2014
We read with interest the recent report by members of the SPARC (Study of Myocardial Perfusion and Coronary Anatomy Imaging Roles in Coronary Artery Disease) Study [(1)][1]. The authors found, on the basis of their interpretation of the results, that “costs were significantly lower after ...
Lundbye, Justin B., Heller, Gary V.
openaire   +2 more sources

SPARC is a Novel Prognostic Biomarker for Ovarian Cancer and Associated with Immune Signatures and Drug Response

Clinical and Experimental Obstetrics & Gynecology
Background: The calcium-binding matricellular glycoprotein (SPARC, secreted protein, acidic and rich in cysteine) belongs to the extracellular-matrix-protein family, and its functions mainly focus on tissue injury, remodeling, and tumorigenesis. The role
Xiaorong Guo, Huilin Tai, Xiaoqing Li, Peng Liu, Jin Liu, Shan Yu   +5 more
doaj   +1 more source

SPARC and GluA1-Containing AMPA Receptors Promote Neuronal Health Following CNS Injury

Frontiers in Cellular Neuroscience, 2018
The proper formation and maintenance of functional synapses in the central nervous system (CNS) requires communication between neurons and astrocytes and the ability of astrocytes to release neuromodulatory molecules.
Emma V. Jones, Yann Bernardinelli, Juan G. Zarruk, Sabrina Chierzi, Keith K. Murai   +4 more
doaj   +1 more source

SPARC: SODA, an interactive software for curating SPARC datasets

The FASEB Journal, 2020
In this era of data‐intensive research, data sharing and reuse are becoming increasingly important for rapid discovery and innovation. While sharing can be as easy as a few clicks thanks to numerous data sharing platforms, data reuse is still an issue as standards for data curation and annotation are not ...
Bhavesh Patel, Harshit Srivastava, Parya Aghasafari, Karl Helmer   +3 more
openaire   +1 more source

SPARC Levels Modulate the Capacity of Mitomycin to Inhibit the Proliferation of Human Tenon’s Capsule Fibroblasts

Journal of Ophthalmology, 2020
Purpose. To evaluate the role of SPARC in the antiproliferation effect of MMC on human Tenon’s fibroblasts (HTF). Method. Sixteen PACG patients aged 59 ± 10 years (31–72 years), including 6 males and 10 females, were recruited. Tenon tissue was harvested
Yuanyuan Guo, Shouxiang Ni, Weiyan Zhou, Jiangping Hou, Jiaquan Shen   +4 more
doaj   +1 more source