Results 41 to 50 of about 22,630 (210)

Association between SPARC mRNA expression, prognosis and response to neoadjuvant chemotherapy in early breast cancer: a pooled in-silico analysis. [PDF]

PLoS ONE, 2013
INTRODUCTION: SPARC is an important regulator of the extracellular matrix and has been suggested to improve delivery of albumin-bound cytotoxics. However, little is known regarding its role in breast cancer (BC).
Hatem A Azim, Sandeep Singhal, Michail Ignatiadis, Christine Desmedt, Debora Fumagalli, Isabelle Veys, Denis Larsimont, Martine Piccart, Stefan Michiels, Christos Sotiriou   +9 more
doaj   +1 more source

Glucocorticoid Receptor Signaling in Myeloid Cells Orchestrates Inflammation Resolution and Muscle Repair

Advanced Science, EarlyView.
Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Sirine Souali‐Crespo, Joe G. Rizk, Emilia Calvano, Rajesh Sahu, Emina Colovic, Imane Chabba, Valentine Gilbart, Erwan Grandgirard, Bastien Morlet, Qingshuang Cai, Daniel Metzger, Delphine Duteil   +11 more
wiley   +1 more source

Prostaglandin E2 depolarises sensory axons in vitro in an ANO1 and Nav1.8 dependent manner

Scientific Reports
Prostaglandin E2 (PGE2) is a major contributor to inflammatory pain hyperalgesia, however, the extent to which it modulates the activity of nociceptive axons is incompletely understood.
Georgios Kimourtzis, Natasha Rangwani, Bethan J. Jenkins, Siddharth Jani, Peter A. McNaughton, Ramin Raouf   +5 more
doaj   +1 more source

Multi‐Tissue Crosstalk Regulating Meniscus Healing Under Inflammation and Physiological Loading

Advanced Science, EarlyView.
Using a novel Meniscus‐on‐a‐chip (MoC) model integrated with a meniscus‐specific bioreactor, this study investigated the roles of multi‐tissue crosstalk that regulates injury, healing, and degeneration of the meniscus injury under inflammation and pathophysiological loading.
Hun Jin Jeong, Elen Zhu, Min Seo Kang, Ming Wang, Sam Comito, Chang H. Lee   +5 more
wiley   +1 more source

Sparc Suppresses Microglial Neuroinflammation and Promotes Axonal Regeneration by Interacting With Uba52

Frontiers in Bioscience-Landmark
Background: After spinal cord injury (SCI), pro-inflammatory microglia accumulate and impede axonal regeneration. We explored whether secreted protein acidic and rich in cysteine (Sparc) restrains microglial inflammation and fosters ...
Hangyu Ji, Kun Wang, Yili Hu, Yefu Xu, Jiangkai Yu, Chengming Li   +5 more
doaj   +1 more source

Downregulation of SPARC expression decreases gastric cancer cellular invasion and survival

Journal of Experimental & Clinical Cancer Research, 2010
Background Secreted protein acidic and rich in cysteine (SPARC) plays a key role in the development of many tissues and organ types. Aberrant SPARC expression was found in a wide variety of human cancers, contributes to tumor development.
Wang Xin, Wan Yuanlian, Wang Pengyuan, Liu Si, Liu Yucun, Chen Guowei, Yin Jie, Zhu Jing, Gao Hongqiao   +8 more
doaj   +1 more source

Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications

Advanced Science, EarlyView.
Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen, Jiahui Lai, Qiongjiao Zeng, Liangbin Zhou, Boguang Yang, Bin Zhang, Min Wang, Jiajing Zhou, Kieran Lau, Khoon S. Lim, Zhong Alan Li, Rocky S. Tuan   +11 more
wiley   +1 more source

Robust reanalysis of the electron radiation belt dynamics for physics driven space climatology applications

Journal of Space Weather and Space Climate
Specification models for radiation belts are essential for the design of radiation resistant, long-lasting spacecraft. Using the available in-situ measurements allows these models to virtually describe the average space radiation environment.
Dahmen Nour, Papadimitriou Constantinos, Brunet Antoine, Sicard Angélica, Aminalragia-Giamini Sigiava, Sandberg Ingmar   +5 more
doaj   +1 more source

Elevated plasma SPARC levels are associated with insulin resistance, dyslipidemia, and inflammation in gestational diabetes mellitus. [PDF]

PLoS ONE, 2013
OBJECTIVE: Recent studies suggested that secreted protein acidic and rich in cysteine (SPARC), a novel adipokine, is a key player in the pathology of obesity and type 2 diabetes.
Lu Xu, Fan Ping, Jinhua Yin, Xinhua Xiao, Hongding Xiang, Christie M Ballantyne, Huaizhu Wu, Ming Li   +7 more
doaj   +1 more source

Sheep Horn Development Revealed by Multi‐Tissue and Cross‐Species Transcriptomic Analysis

Animal Research and One Health, EarlyView.
Multi‐tissue and cross‐species transcriptomics with allele‐specific expression show sheep horns are a composite organ integrating epidermal and osteogenic programs. Conserved horn gene modules and cis‐regulatory variation fine‐tune expression networks underlying horn development and size (small scurs vs. large spiral horns).
Hao Li, Yuchen He, Yangshuo Hu, Naominggaowa, Huaiqiang Yang, Zhu Meng, Fei Liu, Shiwen Zhang, Yi Jin, Mingxing Chu, Zhangyuan Pan   +10 more
wiley   +1 more source