Results 61 to 70 of about 29,961 (262)

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

Advanced Science, EarlyView.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh, Hosni Cherif, Matthew Mannarino, Juiena Sagir, Magali Millecamps, Jean A. Ouellet, Laura S. Stone, Lisbet Haglund   +7 more
wiley   +1 more source

Sparc Suppresses Microglial Neuroinflammation and Promotes Axonal Regeneration by Interacting With Uba52

Frontiers in Bioscience-Landmark
Background: After spinal cord injury (SCI), pro-inflammatory microglia accumulate and impede axonal regeneration. We explored whether secreted protein acidic and rich in cysteine (Sparc) restrains microglial inflammation and fosters ...
Hangyu Ji, Kun Wang, Yili Hu, Yefu Xu, Jiangkai Yu, Chengming Li   +5 more
doaj   +1 more source

The Trichinella Super‐Pangenome Reveals the Evolution of Encapsulation and Predicted Host–Parasite Protein Interactions

Advanced Science, EarlyView.
ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv, Yi Liu, Ning Xu, Xiao Zhang, Yaming Yang, Chengyao Li, Hanhai Mao, Mingyuan Liu, Xiaolei Liu   +8 more
wiley   +1 more source

Overview of the SPARC tokamak [PDF]

, 2020
The SPARC tokamak is a critical next step towards commercial fusion energy. SPARC is designed as a high-field (T), compact (m, m), superconducting, D-T tokamak with the goal of producing fusion gain 2$]]> from a magnetically confined fusion plasma for ...
Vallhagen, Oskar, Särkimäki, K., Sciortino, F., , SPARC Team, Wukitch, S. J.,, Paz-Soldan, C.,, Rodriguez-Fernandez, P.,, Zhu, J., LaBombard, B.,, Wright, J. C.,, Snicker, A.; id_orcid, Scott, S. D., Howard, N. T.,, Snicker, A.,, Canik, J., Granetz, R., Wright, J. C., Lin, Yijun, S\ue4rkim\ue4ki, Konsta, Snyder, P. B.,, Whyte, D. G.,, Sweeney, R.,, Vallhagen, O., Fülöp, Tünde,, Reinke, M. L., Varje, J., Sciortino, F.,, Greenwald, M. J., Wukitch, S. J., Lipschultz, B., Scott, S.D., Tolman, E. A.,, Varje, J.,, Tinguely, R. A., Howard, N. T., Vallhagen, Oskar,, Lore, J. D.,, Granetz, R.,, Rea, C.,, Canik, J.,, Lin, Y.,, Brunner, D.,, Reinke, M. L.,, Lore, J. D., Hughes, J. W.,, Rodriguez-Fernandez, P., Mumgaard, R. T.,, Brunner, D., Scott, S. D.,, Kuang, A. Q.,, Irby, J. H.,, Garnier, D. T., Gray, T. K., Kramer, G. J., Labombard, B., Sorbom, B. N.,, Creely, A. J.,, Hughes, J. W., Sweeney, R., Snicker, A., Rea, C., Ballinger, S. B.,, Sorbom, B. N., Ballinger, S. B., Kramer, G. J.,, Umansky, M., Fülöp, T., Holland, C., Tinguely, R. A.,, Marmar, E. S., Paz-Soldan, C., Whyte, D. G., Gray, T. K.,, Doody, J.,, Kuang, A. Q., Doody, J., Izzo, V. A.,, Umansky, M.,, Logan, N. C., Greenwald, M. J.,, Creely, A. J., Zhu, J.,, SPARC Team, The,, Garnier, D. T.,, Logan, N. C.,, Tolman, E. A., Mumgaard, R. T., Holland, C.,, Wright, J.C., Irby, J. H., Izzo, V. A., Snyder, P. B., Lipschultz, B.,, Lin, Y., Montes, K., Särkimäki, Konsta,, F\ufcl\uf6p, T\ufcnde, Marmar, E. S.,, SPARC Team, The, Montes, K.,   +99 more
core   +1 more source

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source

Impaired wound healing in mice deficient in a matricellular protein SPARC (osteonectin, BM-40)

BMC Cell Biology, 2001
Background SPARC is a matricellular protein involved in cell-matrix interactions. From expression patterns at the wound site and in vitro studies, SPARC has been implicated in the control of wound healing.
Kligman Lorraine H, Basu Amitabha, Samulewicz Stefan J, Howe Chin C   +3 more
doaj   +1 more source

A benchmark dataset for binary segmentation and quantification of dust emissions from unsealed roads

Scientific Data, 2023
The generation of reference data for machine learning models is challenging for dust emissions due to perpetually dynamic environmental conditions.
Asanka De Silva, Rajitha Ranasinghe, Arooran Sounthararajah, Hamed Haghighi, Jayantha Kodikara   +4 more
doaj   +1 more source

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

SPARC

, 2016
We have a new paper that introduces SPARC: Spitzer Photometry & Accurate Rotation Curves. SPARC is a database of 175 galaxies with measured HI rotation curves and homogeneous near-infrared [3.6 micron] surface photometry obtained with the Spitzer Space Telescope. It provides the largest cohesive dataset currently available of ...
openaire   +2 more sources

SPARC–Dependent Cardiomyopathy in Drosophila [PDF]

Circulation: Cardiovascular Genetics, 2016
Background— The Drosophila heart is an important model for studying the genetics underpinning mammalian cardiac function. The system comprises contractile cardiomyocytes, adjacent to which are pairs of highly endocytic pericardial nephrocytes that modulate cardiac function by ...
Hartley, Paul S., Motamedchaboki, K., Bodmer, R., Ocorr, K.   +3 more
openaire   +2 more sources