Results 61 to 70 of about 22,630 (210)

Drosophila SPARC collagen IV chaperone-like activity essential for development is unique to the fat body

iScience
Summary: Drosophila fat body-derived SPARC acts as a chaperone for collagen IV (Col(IV)), enabling their diffusion and incorporation into distal tissue basement membranes (BMs). Disruption of SPARC or Col(IV) production by the fat body is lethal, despite
Samuel Delage, Arya Zadhoosh, William You, Theodore Joseph Brown, Maurice Joseph Ringuette   +4 more
doaj   +1 more source

SPARC: a new approach to quantifying gait smoothness in patients with Parkinson’s disease

Journal of NeuroEngineering and Rehabilitation, 2018
Background Impairments in biomechanics and neural control can disrupt the timing and muscle pattern activation necessary for smooth gait. Gait is one of the most affected motor characteristics in Parkinson’s disease (PD), but its smoothness has not been ...
Yoav Beck, Talia Herman, Marina Brozgol, Nir Giladi, Anat Mirelman, Jeffrey M. Hausdorff   +5 more
doaj   +1 more source

The SPARC initiative: a catalyst for change

Liber Quarterly: The Journal of European Research Libraries, 2004
SPARC was started in 1997 by a number of large research libraries in the US. Its main goal was to restore a competitive balance of the STM journals publishing market.
Bas Savenije
doaj   +1 more source

SPARC Negatively Correlates With Prognosis After Transarterial Chemoembolization and Facilitates Proliferation and Metastasis of Hepatocellular Carcinoma via ERK/MMP Signaling Pathways

Frontiers in Oncology, 2020
Background: Transarterial chemoembolization (TACE) represents a widely accepted treatment procedure for intermediate stage or unresectable hepatocellular carcinoma (HCC).
Yao Liu, Ying Feng, Xiaojing Wang, Xue Yang, Ying Hu, Yuxin Li, Qun Zhang, Yunyi Huang, Ke Shi, Chongping Ran, Jie Hou, Li Jiang, Junfa Li, Xianbo Wang   +13 more
doaj   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Dissecting the angiogenic mechanism of pachychoroid polypoidal choroidal vasculopathy

iMeta, EarlyView.
A prognosis‐oriented classification system was established to distinguish Pachy PCV from Non‐pachy PCV using a large multicenter dataset. Comparative plasma multi‐omics profiling of Pachy PCV, Non‐pachy PCV, and normal controls revealed unique upregulation of the fluid shear stress and atherosclerosis (FSS‐AS) and HIF‐1 signaling pathways in Pachy PCV.
Xinyu Zhao, Tiantian Cheng, Wenfei Zhang, Xingwang Gu, Qing Zhao, Yaning Chen, Lihui Meng, Jiaqi Zhang, Bintao Qiu, Lili Li, Shiyu Cheng, Zicheng Wang, Chuting Wang, Yuelin Wang, Zuyi Yang, Zhengming Shi, Ye Guo, Shengzhi Liu, Youxin Chen   +18 more
wiley   +1 more source

Plasmon–Exciton Coupling Enhances Second‐Order Nonlinear Response in Borophene–ZnO Hybrid Structures

Laser &Photonics Reviews, EarlyView.
Nonlinear interactions between plasmons in borophene and excitons in ZnO lead to enhanced nonlinear and incoherent cathodoluminescence, as well as coherent second harmonic generation, under electron‐beam and laser irradiations, respectively. The anisotropic response of borophene, revealed as in‐plane hyperbolic polariton propagation, acts as a control ...
Maximilian Black, Yaser Abdi, Prabhdeep Singh, Bharti Garg, Zahra Alavi, Mohammadreza Alikhanim, Mohammad Hosein Salemi Seresht, Fatemeh Chahshouri, Masoud Taleb, Nahid Talebi   +9 more
wiley   +1 more source

Kinematic Features of Voluntary and Involuntary Head Movements in Cervical Dystonia

Movement Disorders, EarlyView.
Abstract Background Cervical dystonia (CD) has a varied motor presentation, combining abnormal postures with complex involuntary head movements. Classification of these motor patterns remains imprecise, relying on descriptive terminology without robust definitions. Objectives To provide a kinematically‐grounded description of the motor phenomenology of
Thomas Hart, Davide Martino, Larissa R. Heideman, Martijn Beudel, Mark J. Edwards, Anna Sadnicka, Francesca Morgante   +6 more
wiley   +1 more source

SPARC expression in CML is associated to imatinib treatment and to inhibition of leukemia cell proliferation

BMC Cancer, 2013
Background SPARC is a matricellular glycoprotein with growth-inhibitory and antiangiogenic activity in some cell types. The study of this protein in hematopoietic malignancies led to conflicting reports about its role as a tumor suppressor or promoter ...
Giallongo Cesarina, La Cava Piera, Tibullo Daniele, Barbagallo Ignazio, Parrinello Nunziatina, Cupri Alessandra, Stagno Fabio, Consoli Carla, Chiarenza Annalisa, Palumbo Giuseppe A, Di Raimondo Francesco   +10 more
doaj   +1 more source

Treg‐stromal cell axis in tissue repair and autoimmune diseases: Mechanisms and clinical translation

Rheumatology &Autoimmunity, EarlyView.
The Treg‐stromal cell axis as a central regulator of tissue repair and immune tolerance. Under physiological conditions, bidirectional communication between Tregs and stromal cells—mediated by cell‐surface molecular contacts, anti‐inflammatory cytokines, and extracellular vesicles—orchestrates inflammation resolution, immune tolerance, and complete ...
Peiyan Zhang, Rongyuan Gao, Zhaohui Zheng   +2 more
wiley   +1 more source