Results 71 to 80 of about 29,961 (262)

Condition‐Associated Pattern Extraction and Recovery From Multi‐Condition Single‐Cell RNA‐seq Data With CAPER

Advanced Science, EarlyView.
Decoupling biological signals from unwanted variation in multi‑condition single‑cell RNA sequencing data remains challenging. CAPER disentangles condition‑associated biological effects from sample heterogeneity through matrix factorization, producing interpretable latent factors and a batch‑corrected expression matrix.
Ye Li, Jin Ning, An Wang, Minxi Shi, Yuanze Chen, Guoliang Liu, Shiquan Sun   +6 more
wiley   +1 more source

Drosophila SPARC collagen IV chaperone-like activity essential for development is unique to the fat body

iScience
Summary: Drosophila fat body-derived SPARC acts as a chaperone for collagen IV (Col(IV)), enabling their diffusion and incorporation into distal tissue basement membranes (BMs). Disruption of SPARC or Col(IV) production by the fat body is lethal, despite
Samuel Delage, Arya Zadhoosh, William You, Theodore Joseph Brown, Maurice Joseph Ringuette   +4 more
doaj   +1 more source

SPARC overexpression inhibits cell proliferation in neuroblastoma and is partly mediated by tumor suppressor protein PTEN and AKT.

PLoS ONE, 2012
Secreted protein acidic and rich in cysteine (SPARC) is also known as BM-40 or Osteonectin, a multi-functional protein modulating cell-cell and cell-matrix interactions.
Praveen Bhoopathi, Bharathi Gorantla, G S Sailaja, Christopher S Gondi, Meena Gujrati, Jeffrey D Klopfenstein, Jasti S Rao   +6 more
doaj   +1 more source

SPARC Negatively Correlates With Prognosis After Transarterial Chemoembolization and Facilitates Proliferation and Metastasis of Hepatocellular Carcinoma via ERK/MMP Signaling Pathways

Frontiers in Oncology, 2020
Background: Transarterial chemoembolization (TACE) represents a widely accepted treatment procedure for intermediate stage or unresectable hepatocellular carcinoma (HCC).
Yao Liu, Ying Feng, Xiaojing Wang, Xue Yang, Ying Hu, Yuxin Li, Qun Zhang, Yunyi Huang, Ke Shi, Chongping Ran, Jie Hou, Li Jiang, Junfa Li, Xianbo Wang   +13 more
doaj   +1 more source

BIG-SPARC: The new SPARC database

To be published in the proceedings of IAU Symposium 392 "Neutral Hydrogen in and around Galaxies in the SKA Era", 6 pages, 3 figures, 1 ...
Haubner, Konstantin, Lelli, Federico, Di Teodoro, Enrico, Duey, Francis, McGaugh, Stacy, Schombert, James, Hess, Kelley M., Team, the Apertif   +7 more
openaire   +2 more sources

Report on the 25th SPARC Scientific Steering Group Meeting, 16-18 October 2017, Incheon, South Korea [PDF]

, 2018
The 25th SPARC Scientific Steering Group (SSG) meeting was jointly hosted by colleagues affiliated at the Seoul National University (SNU) and the Korean Polar Research Institute (KOPRI).
Harris, Neil, Perlwitz, Judith, Volkert, Hans   +2 more
core  

SPARC: a new approach to quantifying gait smoothness in patients with Parkinson’s disease

Journal of NeuroEngineering and Rehabilitation, 2018
Background Impairments in biomechanics and neural control can disrupt the timing and muscle pattern activation necessary for smooth gait. Gait is one of the most affected motor characteristics in Parkinson’s disease (PD), but its smoothness has not been ...
Yoav Beck, Talia Herman, Marina Brozgol, Nir Giladi, Anat Mirelman, Jeffrey M. Hausdorff   +5 more
doaj   +1 more source

A Denotational Semantics for SPARC TSO

Logical Methods in Computer Science, 2018
The SPARC TSO weak memory model is defined axiomatically, with a non-compositional formulation that makes modular reasoning about programs difficult. Our denotational approach uses pomsets to provide a compositional semantics capturing exactly the behaviours permitted by SPARC TSO.
Ryan Kavanagh, Stephen Brookes
openaire   +5 more sources

SPARC/osteonectin in mineralized tissue [PDF]

Matrix Biology, 2016
Secreted protein acidic and rich in cysteine (SPARC/osteonectin/BM40) is one of the most abundant non-collagenous protein expressed in mineralized tissues. This review will focus on elucidating functional roles of SPARC in bone formation building upon results from non-mineralized cells and tissues, the phenotype of SPARC-null bones, and recent ...
Emilie M, Rosset, Amy D, Bradshaw
openaire   +2 more sources

Sheep Horn Development Revealed by Multi‐Tissue and Cross‐Species Transcriptomic Analysis

Animal Research and One Health, EarlyView.
Multi‐tissue and cross‐species transcriptomics with allele‐specific expression show sheep horns are a composite organ integrating epidermal and osteogenic programs. Conserved horn gene modules and cis‐regulatory variation fine‐tune expression networks underlying horn development and size (small scurs vs. large spiral horns).
Hao Li, Yuchen He, Yangshuo Hu, Naominggaowa, Huaiqiang Yang, Zhu Meng, Fei Liu, Shiwen Zhang, Yi Jin, Mingxing Chu, Zhangyuan Pan   +10 more
wiley   +1 more source