Results 51 to 60 of about 29,961 (262)

SPARC is a Novel Prognostic Biomarker for Ovarian Cancer and Associated with Immune Signatures and Drug Response

Clinical and Experimental Obstetrics & Gynecology
Background: The calcium-binding matricellular glycoprotein (SPARC, secreted protein, acidic and rich in cysteine) belongs to the extracellular-matrix-protein family, and its functions mainly focus on tissue injury, remodeling, and tumorigenesis. The role
Xiaorong Guo, Huilin Tai, Xiaoqing Li, Peng Liu, Jin Liu, Shan Yu   +5 more
doaj   +1 more source

Association between SPARC mRNA expression, prognosis and response to neoadjuvant chemotherapy in early breast cancer: a pooled in-silico analysis. [PDF]

PLoS ONE, 2013
INTRODUCTION: SPARC is an important regulator of the extracellular matrix and has been suggested to improve delivery of albumin-bound cytotoxics. However, little is known regarding its role in breast cancer (BC).
Hatem A Azim, Sandeep Singhal, Michail Ignatiadis, Christine Desmedt, Debora Fumagalli, Isabelle Veys, Denis Larsimont, Martine Piccart, Stefan Michiels, Christos Sotiriou   +9 more
doaj   +1 more source

A Fully Human Engineered Bone Niche With Endogenous Osteoclastogenesis Reveals Osteoclast‐Dependent Osteomimicry in Prostate Cancer Cells

Advanced Healthcare Materials, EarlyView.
A human 3D bone niche integrating osteoblasts and osteoclasts enables co‐culture with prostate cancer cell lines and patient‐derived organoids. The engineered niche (i) models aspects of reciprocal phenotypic regulation between osteoblasts and cancer cells, (ii) captures osteoclast‐enhanced osteomimicry in tumor cells, and (iii) establishes a ...
Andrea Mazzoleni, Robin Dolgos, Thomas Menter, Boris Dasen, Arnaud Scherberich, Clémentine Le Magnen, Manuele G. Muraro, Ivan Martin   +7 more
wiley   +1 more source

Impressions from the SPARC General Assembly [PDF]

, 2019
A grouped collage of photographs taken during the SPARC General Assembly in Kyoto, Japan, 1-5 October ...
Volkert, Hans
core  

SPARC and GluA1-Containing AMPA Receptors Promote Neuronal Health Following CNS Injury

Frontiers in Cellular Neuroscience, 2018
The proper formation and maintenance of functional synapses in the central nervous system (CNS) requires communication between neurons and astrocytes and the ability of astrocytes to release neuromodulatory molecules.
Emma V. Jones, Yann Bernardinelli, Juan G. Zarruk, Sabrina Chierzi, Keith K. Murai   +4 more
doaj   +1 more source

SPARC Levels Modulate the Capacity of Mitomycin to Inhibit the Proliferation of Human Tenon’s Capsule Fibroblasts

Journal of Ophthalmology, 2020
Purpose. To evaluate the role of SPARC in the antiproliferation effect of MMC on human Tenon’s fibroblasts (HTF). Method. Sixteen PACG patients aged 59 ± 10 years (31–72 years), including 6 males and 10 females, were recruited. Tenon tissue was harvested
Yuanyuan Guo, Shouxiang Ni, Weiyan Zhou, Jiangping Hou, Jiaquan Shen   +4 more
doaj   +1 more source

Elevated plasma SPARC levels are associated with insulin resistance, dyslipidemia, and inflammation in gestational diabetes mellitus. [PDF]

PLoS ONE, 2013
OBJECTIVE: Recent studies suggested that secreted protein acidic and rich in cysteine (SPARC), a novel adipokine, is a key player in the pathology of obesity and type 2 diabetes.
Lu Xu, Fan Ping, Jinhua Yin, Xinhua Xiao, Hongding Xiang, Christie M Ballantyne, Huaizhu Wu, Ming Li   +7 more
doaj   +1 more source

Mechanically Spatio‐Chimeric Fibrin Assembly Enables Vascular‐Integrated Muscle Reconstruction for Volumetric Muscle Loss Repair

Advanced Materials, EarlyView.
SPARC (spatio‐chimeric, plasma‐based, anisotropic, and shear‐responsive construct) that integrates myogenic and vascular microenvironments within a single construct. The dual‐modulus matrix directs aligned myotube formation and endothelial network development, enabling a vascularized muscle implant that seamlessly anastomoses with host tissue and ...
Su Hyun Jung, Minjun Kim, Da‐Yoon Kim, Min Kyu Kim, Sieun Lee, Yoonhee Jin, Joo H. Kang   +6 more
wiley   +1 more source

Downregulation of SPARC expression decreases gastric cancer cellular invasion and survival

Journal of Experimental & Clinical Cancer Research, 2010
Background Secreted protein acidic and rich in cysteine (SPARC) plays a key role in the development of many tissues and organ types. Aberrant SPARC expression was found in a wide variety of human cancers, contributes to tumor development.
Wang Xin, Wan Yuanlian, Wang Pengyuan, Liu Si, Liu Yucun, Chen Guowei, Yin Jie, Zhu Jing, Gao Hongqiao   +8 more
doaj   +1 more source

SPARC: SODA, an interactive software for curating SPARC datasets

The FASEB Journal, 2020
In this era of data‐intensive research, data sharing and reuse are becoming increasingly important for rapid discovery and innovation. While sharing can be as easy as a few clicks thanks to numerous data sharing platforms, data reuse is still an issue as standards for data curation and annotation are not ...
Bhavesh Patel, Harshit Srivastava, Parya Aghasafari, Karl Helmer   +3 more
openaire   +1 more source