Results 11 to 20 of about 22,630 (210)

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency. [PDF]

Adv Sci (Weinh)
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Yang Q, Jiang H, Xiong C, Zhou X, Tan Q, Xiao H, Qiu L, Gan C, Chen Y, Yang H, Jiang W, Li Q.   +11 more
europepmc   +2 more sources

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

SPARC Expression Is Selectively Suppressed in Tumor Initiating Urospheres Isolated from As+3- and Cd+2-Transformed Human Urothelial Cells (UROtsa) Stably Transfected with SPARC. [PDF]

PLoS ONE, 2016
BACKGROUND:This laboratory previously analyzed the expression of SPARC in the parental UROtsa cells, their arsenite (As(+3)) and cadmium (Cd(+2))-transformed cell lines, and tumor transplants generated from the transformed cells. It was demonstrated that
Andrea Slusser-Nore, Jennifer L Larson-Casey, Ruowen Zhang, Xu Dong Zhou, Seema Somji, Scott H Garrett, Donald A Sens, Jane R Dunlevy   +7 more
doaj   +1 more source

Hypoxic regulation of the expression of anti-angiogenic genes in U87 glioma cells with loss of function of ern1 signaling enzyme

Біологічні студії, 2012
The angiogenesis is an important component of tumor growth and tightly associated with hypoxia. The expression level of genes related to regulation of angiogenesis (BAI2, SPARC, TIMP1, TIMP2, TIMP3, TIMP4, THBS1, THBS2, ADAMTS5 and FGF2) in glioma ...
K. I. Kubaichuk, D. O. Minchenko, S. V. Danilovskyi, A. Y. Kuznetsova, A. K. Jassim, O. H. Minchenko   +5 more
doaj   +1 more source

SPARC regulation of PMN clearance protects from pristane-induced lupus and rheumatoid arthritis

iScience, 2021
Summary: The secreted protein acidic and rich in cysteine (SPARC) is a matricellular protein with unexpected immunosuppressive function in myeloid cells. We investigated the role of SPARC in autoimmunity using the pristane-induced model of lupus that, in
Sabina Sangaletti, Laura Botti, Alessandro Gulino, Daniele Lecis, Barbara Bassani, Paola Portararo, Matteo Milani, Valeria Cancila, Loris De Cecco, Matteo Dugo, Claudio Tripodo, Mario P. Colombo   +11 more
doaj   +1 more source

In Silico Evaluation of Interactions of Triterpenes in Momordica charantia on Proteins Involved in Angiogenesis

Proceedings, 2019
Angiogenesis is important process that play active role in tumorigenesis. VEGFR-1, a member of the tyrosine kinase receptor family, is known as the receptor for VEGF ligands in tumor cells.
Büşra Sevim, Onur Eroğlu
doaj   +1 more source

SPARC Promotes Cell Invasion In Vivo by Decreasing Type IV Collagen Levels in the Basement Membrane. [PDF]

PLoS Genetics, 2016
Overexpression of SPARC, a collagen-binding glycoprotein, is strongly associated with tumor invasion through extracellular matrix in many aggressive cancers.
Meghan A Morrissey, Ranjay Jayadev, Ginger R Miley, Catherine A Blebea, Qiuyi Chi, Shinji Ihara, David R Sherwood   +6 more
doaj   +1 more source

Increased SPARC expression is associated with neoadjuvant therapy in resectable pancreatic ductal adenocarcinoma

Practical Laboratory Medicine, 2020
Secreted Protein Acid and Rich in Cysteine (SPARC) is an extracellular glycoprotein secreted by fibroblasts and osteoblasts in normal tissues. SPARC overexpression occurs in multiple tumors including pancreatic ductal adenocarcinoma (PDAC) and may ...
Christopher Hartley, Daniel Rowan, Xiuxu Chen, Luisa Gomez-Arellano, Anna Marie West, Kiyoko Oshima, Alexander Craig Mackinnon   +6 more
doaj   +1 more source

BIG-SPARC: The new SPARC database

Proceedings of the International Astronomical Union
Abstract The Surface Photometry and Accurate Rotation Curves (SPARC) database has provided the community with mass models for 175 nearby galaxies, allowing different research teams to test different dark matter models, galaxy evolution models, and modified gravity theories.
Konstantin Haubner, Federico Lelli, Enrico Di Teodoro, Francis Duey, Stacy McGaugh, James Schombert, Kelley M. Hess   +6 more
openaire   +3 more sources

Lack of the matricellular protein SPARC (secreted protein, acidic and rich in cysteine) attenuates liver fibrogenesis in mice. [PDF]

PLoS ONE, 2013
INTRODUCTION: Secreted Protein, Acidic and Rich in Cysteine (SPARC) is a matricellular protein involved in many biological processes and found over-expressed in cirrhotic livers.
Catalina Atorrasagasti, Estanislao Peixoto, Jorge B Aquino, Néstor Kippes, Mariana Malvicini, Laura Alaniz, Mariana Garcia, Flavia Piccioni, Esteban J Fiore, Juan Bayo, Ramón Bataller, Elizabeth Guruceaga, Fernando Corrales, Osvaldo Podhajcer, Guillermo Mazzolini   +14 more
doaj   +1 more source