Results 111 to 120 of about 10,433,910 (363)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

URBAN MANAGEMENT– CURRENT STRATEGIC APPROACHES [PDF]

In recent years urban management conceptual evolutions are more and more connected to the chances in public administration practice, in particular to ways of raising efficiency and effectiveness.
Razvan-Andrei CORBOs, Ruxandra-Irina POPESCU   +1 more
core  

Strategic directions of transport and logistics to ensure the implementation of new industrialization processes [PDF]

, 2019
Ensuring the processes of industrialization of the modern economy requires the formation of an efficient transport and logistics infrastructure. The solution of this task is carried out using the tools of strategic management, in particular the formation
Morkonosov, A. G., Ogorodnikova, E. S., Semenet, I. I., Sidorenko, A. M.   +3 more
core  

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Strategic management of population programs [PDF]

Formal strategic planning and management appear to contribute to organizational effectiveness. The author surveys the literature on strategic management in private/for-profit organizations and applies lessons from that literature to population programs ...
Bernhart, Michael H.
core  

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

GWAS shows links between EDARADD and LRFN5 and performance in professional athletes

BMC Sports Science, Medicine and Rehabilitation
Background Research into genetic markers associated with sports performance and aerobic capacity has been gaining momentum. However, despite the discovery of numerous molecular and genetic markers, there is still a gap in understanding the variations in ...
M. V. Terekhov, R. V. Deev, A. I. Kadykova, I. H. Dzhumaniiazova, A. A. Mamchur, E. A. Zelenova, L. R. Matkava, M. V. Ivanov, D. A. Kashtanova, S. I. Mitrofanov, L. A. Golubnikova, A. I. Nekrasova, I. G. Kalashnikova, A. A. Ivashechkin, V. V. Maksyutina, O. V. Varlamova, V. S. Yudin, A. A. Keskinov, A. V. Zholinsky, S. A. Kraevoy, S. M. Yudin, V. I. Skvortsova   +21 more
doaj   +1 more source

Marsh migration and beyond: A scalable framework to assess tidal wetland resilience and support strategic management. [PDF]

PLoS One, 2023
Stevens RA, Shull S, Carter J, Bishop E, Herold N, Riley CA, Wasson K.   +6 more
europepmc   +1 more source

Strategic Management and HRM [PDF]

, 2006
[Excerpt] The purpose of this chapter is to discuss this intersection between Strategic Management and HRM, what we know, and future directions for SHRM research.
Allen, Mathew R., Wright, Patrick M.
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source