Results 121 to 130 of about 2,216,797 (273)

Modern approaches to the immunotherapy of Clostridioides difficile

Журнал инфектологии
Clostridioides difficile is a leading cause of diarrhea and pseudomembranous colitis associated with antibiotic therapy. Hypervirulent strains of C. difficile, such as ribotype 027, have high mortality rates. Recurrent C. difficile infection is extremely
K. E. Popruga, V. V. Makarov
doaj   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

The challenges of strategic management of the wastage produced due to earthquake in Kermanshah and Varzaghan-Ahar: A qualitative study. [PDF]

J Educ Health Promot, 2022
Kazemi S, Mokhtari M, Vaezi A, Salmani I, Ehrampoush MH, Dehghani Tafti AA, Fallahzadeh H, Ardakani MF.   +7 more
europepmc   +1 more source

The elaboration and implementation of a strategic management model on the Romanian market [PDF]

A brilliant business idea does not have the strength to sustain on a long term the development of a small company. This paper offers a model of strategic management which, if adapted, can serve as a guideline for the proper development of a small sized ...
Cristian Costin NEDELCU
core  

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Municipal Pathways in Response to COVID-19: A Strategic Management Perspective on Local Public Administration Resilience. [PDF]

Adm Soc, 2023
Clement J, Esposito G, Crutzen N.
europepmc   +1 more source

Making Sense of Projects—Developing Project Portfolio Management Capabilities

Schmalenbach Journal of Business Research
Project management and project portfolio management (PPM) foster competitiveness by facilitating the implementation of organizational strategy. Although organizations often struggle to develop PPM capabilities, the academic community does not have an in ...
Frederik Ahlemann, Peder Bergan, Erik Karger, Malte Greulich, Stefan Reining   +4 more
doaj   +1 more source

Remodeling of the chromatin landscape in peripheral blood cells in patients with severe Delta COVID-19

Frontiers in Immunology
COVID-19 is characterized by systemic pro-inflammatory shifts with the development of serious alterations in the functioning of the immune system. Investigations of the gene expression changes accompanying the infection state provide insight into the ...
Vasiliy E. Akimov, Dmitriy I. Tychinin, Olga A. Antonova, Abusaid M. Shaymardanov, Maria D. Voronina, Kseniia A. Deinichenko, Oleg D. Fateev, Vladimir S. Yudin, Sergey M. Yudin, Vladimir E. Mukhin, Svetlana V. Romanova, Aleksandra I. Nekrasova, Anastasia S. Zhdanova, Anastasia V. Tsypkina, Ivan S. Vladimirov, Antonida V. Makhotenko, Anton A. Keskinov, Sergey A. Kraevoy, Ekaterina A. Snigir, Dmitry V. Svetlichnyy, Veronika I. Skvortsova   +20 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

The use of the Balanced Scorecard as a strategic management tool to mitigate cyberfraud in the South African banking industry. [PDF]

Heliyon, 2022
Esther Akinbowale O, Eckart Klingelhöfer H, Fekadu Zerihun M.   +2 more
europepmc   +1 more source