Results 221 to 230 of about 1,020,195 (308)

Equality, diversity and inclusion strategies of NIHR biomedical research centres and clinical research facilities across England: a qualitative content analysis. [PDF]

BMJ Open
Hua P, Dawson S, Phillips H.
europepmc   +1 more source

Further Education Funding Council : circular 00/18 : planning : strategic plans, including financial forecasts and accommodation data [PDF]

, 2000

core  

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Planning and Implementing Social Media Communication in a Public Health Crisis: An Analytical Perspective. [PDF]

Health Promot J Austr
Balogun BA, Hogden A, Yang L, Agaliotis M, Kemp N.   +4 more
europepmc   +1 more source

The World Hypertension League challenges hypertension and cardiovascular organizations to develop strategic plans for the prevention and control of hypertension. [PDF]

J Clin Hypertens (Greenwich), 2015
Campbell NR, Lackland DT, Lisheng L, Zhang XH, Nilsson PM, Redburn KA, Niebylski ML.   +6 more
europepmc   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Task sharing for point-of-care testing: Review of national health policies and implementation landscape in 19 African countries. [PDF]

PLOS Glob Public Health
Ndlovu Z, Assane MI, Ocen F, Lamou KC, Mandona M, Mphande-Nyasulu F, Kabwe E, Fongwen NT, Said HM, Emmanuel O, Elom E, Chipuka S, Nabadda S, Bitilinyu-Bangoh J, Lesuk G, Bowen N, Adama D, Mlisana K, George JA, Melese D, Ayana G, Ndombe R, Johnson CC, Bekelynck A, Ondoa P, Loembé MM, Ellman T, Ndlovu N, Fatti G, Otieno Odhiambo C.   +29 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Walking the walk: a case study of partnering with patients in designing and delivering a patient and public involvement implementation plan. [PDF]

Res Involv Engagem
South A, Sturgeon K, Tahsin A, Stephens R.   +3 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source