Results 101 to 110 of about 819,854 (302)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Nuclear Factor and Its Impact on Military Doctrines of the USSR and the USA during the Cold War
СибСкриптThe Cold War doctrines of the USSR and the USA were shaped by the nuclear factor. Today, nuclear deterrence remains a major factor of international security.
Georgy A. Mayorov
doaj +1 more source
Recognizing Risk in Human Capital Investments: A Real Options Approach to Strategic Human Resource Management [PDF]
, 2000 An issue that has not yet been explored in the field of strategic human resource management (SHRM) is that of managing the ‘risks’ involved in human capital management of the firm. We address this issue using the real option theory framework.
Bhattacharya, Mousumi +1 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Preserving and Updating Strategic Stability
, 2023 AbstractA number of justifications of the special military operation launched by Russia on February 24 2022 are officially put forward.
openaire +1 more source
Distributed Mechanism Design with Learning Guarantees
, 2017 Mechanism design for fully strategic agents commonly assumes broadcast nature of communication between agents of the system. Moreover, for mechanism design, the stability of Nash equilibrium (NE) is demonstrated by showing convergence of specific pre ...
Anastasopoulos, Achilleas +1 more
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Economic Security in the Black Sea Region [PDF]
Berry Buzan and the Copenhagen School proposed three new dimensions of security in order to complete it’s the narrow political and military components. These are the economic, societal and environmental dimensions. The result is that economic factor came
Alina Draghici
core
, 2016 Based on the second-order quantum interference between frequency entangled photons that are generated by parametric down conversion, a quantum strategic algorithm for synchronizing two spatially separated clocks has been recently presented.
Dong, Ruifang +8 more
core +1 more source