Results 101 to 110 of about 3,645,679 (303)
Вестник Московского Университета. Серия XXV: Международные отношения и мировая политика, 2020 The book under review is a new seminal work by Andrey A. Kokoshin, the 6th Secretary of the Security Council of the Russian Federation and a member of the Russian Academy of Sciences. The monograph explores a wide range of applied and theoretical aspects
V. A. Zolotarev
doaj
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Small States and the Third Nuclear Age: An Introduction
Scandinavian Journal of Military StudiesWhat is the role of small states in extended nuclear deterrence? In this introductory article we examine how smaller states participate in extended nuclear deterrence arrangements in the Third Nuclear Age.
Målfrid Braut-Hegghammer, Ian Bowers
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Small State Conventional Long-Range Strike Arsenals and Strategic Stability in Europe
Scandinavian Journal of Military StudiesHow does the acquisition of conventional long-range strike weapons (LRS) shape small state warfighting and deterrence strategies, and what implications does this hold for strategic stability? While LRS offer small states new capabilities to threaten high-
Fabian R. Hoffmann
doaj +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Accidental/Inadvertent Indian Missile Launch and Procedural Arms Control in South Asia
Journal for Peace and Nuclear DisarmamentArms control sceptics claim that arms control is either impossible in hostile rivalries or unnecessary in confrontations where disputes are being resolved.
Julian Spencer-Churchill, Nasir Mehmood
doaj +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source