Results 121 to 130 of about 819,854 (302)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Organizational Culture and Relationship Skills [PDF]

open access: yes
While both the strategic management and the network literature recognize the importance of inter-firm relationships for explaining competitive advantage, the question why firms differ in their ability to benefit from these relationships is rarely ...
Beugelsdijk, S.   +2 more
core   +1 more source

On the generic strategic stability of nash equilibria if voting is costly [PDF]

open access: yes, 2002
We prove that for generic plurality games with positive cost of voting, the number of Nash equilibria is finite.
De Sinopoli, Francesco   +1 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Credible Group Stability in Many-to-Many Matching Problems [PDF]

open access: yes
It is known that in two-sided many-to-many matching problems, pairwise stable matchings may not be immune to group deviations, unlike in many- to-one matching problems (Blair 1988). In this paper, we show that pairwise stability is equivalent to credible
Hideo Konishi, M. Utku Ünver
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

IMPORTANCE OF STRATEGIC STABILITY AND COMPETITIVENESS OF BUSINESS ORGANIZATIONS FOR RF INNOVATIVE ECONOMIC DEVELOPMENT

open access: yesМодернизация, инновация, развитие, 2016
Business organization strategic stability and competitiveness concepts are discussed. Relationships between competitiveness and strategic stability indicators are identified, their impact on innovative performance indices are investigated by means of ...
V. A. Radchenko
doaj  

Strategic debt management within the stability and growth pact [PDF]

open access: yes
Opportunistic politicians use the composition of public debt as a signal for competence. A competent government will not issue long-term nominal debt, as optimal to balance the budget, but long-term inflation-indexed debt.
Sieg, Gernot, Stegemann, Ulrike
core  

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