Results 141 to 150 of about 819,854 (302)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Strategic Stability: Contending Interpretations [PDF]
, 2013 Michael S. Gerson, Elbridge A. Colby
openaire +1 more source
HedN Game, a Relational Framework for Network Based Cooperation [PDF]
This paper proposes a new framework for cooperative games based on mathematical relations. Here cooperation is defined as a supportive partnerships represented by a directed network between players (aka hedonic relation). We examine in a specific context,
Franck Delaplace, Pierre Lescanne
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Global Games with Strategic Substitutes [PDF]
In this paper we use a non cooperative equilibrium selection approach as a notion of stability in link formation games. Specifically, we follow the global games approach first introduced by Carlsson and van Damme (1993), to study the robustness of the ...
Rodrigo Harrison & Roberto Munoz
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Small farms in Italy between decline and innovative formula: an entrepreneurial model analysis [PDF]
During the three-year period of our investigation, we found that the weight of family run farms declined and there was an increase in the role of farms integrated in the market and in integrated low-impact farm.
Adinolfi, Felice +2 more
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Antiballistic Systems and Strategic Stability
Czech Journal of Political Science/Politologický časopis, 2002 After the end of the Cold War threats USA are facing changed significantly. In the contemporary international system the greatest challenge is posed by “rogue states“. The threat of attack with the use of weapons of mass destruction is even higher than was during the Cold War Era, because also non-state actors could employ such weapons.
openaire +1 more source