Results 151 to 160 of about 3,645,679 (303)
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Strategic substitutabilities versus strategic complementarities: Towards a general theory of expectational coordination? [PDF]
This paper contrasts the views of expectational coordination in a stylised economic model under two polar assumptions: Strategic Complementarities (StCo) dominate or on the contrary are dominated by Strategic Substitutabilities (StSu).
Roger Guesnerie
core
Governing digital misinformation: A computational analysis of platform intervention using a three-party evolutionary game model. [PDF]
PLoS OneZhang Y, Song X.
europepmc +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
The biosecurity busyness paradox: Why doing more and remaining consistent may be undermining global resilience. [PDF]
One HealthMcDonald JI.
europepmc +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Experimental Study of a Digital Feedback Fluxgate Magnetometer Using a Fifth-Order Single-Loop 1-Bit Sigma-Delta Modulator. [PDF]
Sensors (Basel)Lv S, Wang J, Zhang Y, Cui X.
europepmc +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Evolutionary game-theoretic modeling of electricity market dynamics for elastic load optimization. [PDF]
Sci RepPrakash RV, Rengaraj R.
europepmc +1 more source