Results 71 to 80 of about 4,753,726 (342)

Innovative foresight as a tool for shaping development strategy business structures

open access: yesПутеводитель предпринимателя, 2020
To obtain stable and distinctive competitive advantages that make strategic competitiveness, entrepreneurs must have the knowledge-component development, including the ability to produce and innovate in their management systems. The article discusses the

doaj  

The U.S. and Allies’ Forward-Based BMD Systems: An Emerging Threat to Strategic Stability

open access: yesМеждународная аналитика, 2017
The subject of this expert study is an evaluation of risks and potential threats of globalization of the U.S. and the allied BMD systems as well as of their sea-based deployments as the most important component of integrated forward-based BMD systems ...
I. Kuznetsov
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Making a comprehensive arms control agreement for Europe in times of crisis: Rationale, structure, and outcomes [PDF]

open access: yesPolitika nacionalne bezbednosti
The war in Ukraine reflects the culmination of two international crises - one of the European security architecture and the other of strategic stability.
Stefanović Andrej   +1 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

The Deep Crisis of Nuclear Arms Control and Disarmament: The State of Play and the Challenges

open access: yesJournal for Peace and Nuclear Disarmament, 2019
After the golden age of arms control, Russia and the United States are no longer engaged in arms control negotiations. The landmark Intermediate-Range Nuclear Forces (INF) Treaty was officially terminated on 2 August 2019, and the New Strategic Arms ...
Götz Neuneck
doaj   +1 more source

New Aspects of National Security Startegy

open access: yesVestnik MGIMO-Universiteta, 2012
The article describes new aspects in the development of contemporary international security situation and strategic stability. The author opines that the current phase of international relations tends to be rather chaotic and highly unpredictable in its ...
V. I. Mizin
doaj   +1 more source

Strategic Stability in South Asia; Strategic Insights, v. 3, issue 8 (August 2004) [PDF]

open access: yes, 2004
This article appeared in Strategic Insights, v.3, issue 8 August 2004)Approved for public release; distribution is ...
Clary, Christopher, Lavoy, Peter R.
core  

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

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