Results 91 to 100 of about 49,914 (298)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Conceptual Pattern of Strategic Thinking in Business from the Viewpoint of Imam Ali (A.S.) in Nahjolbalagheh [PDF]

open access: yesاسلام و مدیریت
Numerous management papers emphasizes the importance of strategic thinking among managers, but the issue that has been paid less attention is the link between strategic thinking and values. This link connects moralities with business logic.
aliasghar shirepaz   +3 more
doaj  

The Effectiveness of Teaching Mechanics Using Practical Experiments in Developing Strategic Competence and Design Thinking for STEM School Students [PDF]

open access: yesمجلة تربويات الرياضيات
The research aimed to identify the effectiveness of teaching the mechanics curriculum using practical experiments in developing strategic competence and design thinking among STEM school students.
Reda Mossad Elsaid   +1 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Leadership Styles and Strategic Thinking in Organizational Level [PDF]

open access: yesمطالعات مدیریت راهبردی, 2013
Today, organizations are faced with some problems due to sever changes in technology and environment and these problems are complicated more and more.
Emad Golmohammadi   +2 more
doaj  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Correlations of strategic thinking with business decisions.

open access: yes, 2013
Master thesis subject is the correlations of strategic thinking with business decisions. In order to analyze this subject, the goal was to find correlations of strategic thinking with business decisions and present an interaction model of strategic ...
Šimkuvienė, Lina,
core  

Strategic Thinking and Dimensions of Effective Leadership

open access: yes, 2018
WOS: 000444687500010The concept of strategic thinking, which becomes a necessity in today's management understanding, requires to think about every issue which is meaningful from strategic point of view.
Zorlu, Kursad, Kürşad Zorlu
core   +1 more source

The Impact of Strategic Management and Strategic Thinking Approaches on Business Performance of Companies Operating in the Retail Industry [PDF]

open access: yesEuropean Project Management Journal, 2017
The research paper investigated the impact of strategic management and thinking on increased business performance of retail industry businesses. It reviewed the case of Tesco Plc in retail industry and evaluated how effectively management of the business
Miloš Lončar
doaj  

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