Results 131 to 140 of about 8,270,702 (310)
Management of Innovations: Current Problem in the Management of Soviet Science and Technology [PDF]
, 1975 The object of this paper is to summarize some aspects of the management of scientific and technological development (STD) in the Soviet Union, its present problems, and some indications of their solutions. In this paper, of course, only a short survey is
Sobrovine, A.
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
THE MANAGEMENT OF SCIENTIFIC RESEARCH AND ITS PLACE IN THE UNIVERSITY ACTIVITY [PDF]
In the last two decades, the research in general and in particular the universities research has gained a special importance. The competition for the resources and in particular for the human resources, the higher education transformations in recent ...
Loredana VÄ‚CÄ‚RESCU HOBEANU
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A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Integrated Administration of the Organizations Informational Resources [PDF]
Organizations grow and develop continuosly and information volume grows in the same rythm, which makes from improvement or changing the old counting systems an imperative.
Carmen COMANICIU +3 more
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Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Operational and real-time Business Intelligence [PDF]
A key component of a company’s IT framework is a business intelligence (BI) system. BI enables business users to report on, analyze and optimize business operations to reduce costs and increase revenues.
Daniela Ioana SANDU
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Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
Molecular Oncology, EarlyView.PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga +2 more
wiley +1 more source
THE ROLE OF INFORMATION FOR GLOBAL MARKETING - EDUCATIONAL AND PRACTICAL ASPECTS [PDF]
The selection of company strategy for international market appearance is an essential part of implementation the global marketing. Given the fact that this process is influenced by a diverse range of factors, it is necessary to research and report ...
Tatjana Petkovska Mirchevska
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