Results 71 to 80 of about 1,157 (260)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
The Adoption of Marketing Decisions by Using Fuzzy Logic for Market Segmentation and Competitive Advantage Achieving A Hypothetical Application in Automotive Industry [PDF]
Ovidius University Annals: Economic Sciences Series, 2018 In our contemporary period the businesses environment becomes more and more dynamicallyand surrounded by uncertainty, in the same time with the continuous increase of globalization andtechnology development.
Sîrb Lucian +2 more
doaj
Strategic management of outsourcing [PDF]
, 2014 The monograph deals with outsourcing from the point of view of Slovenian enterprises, which accept outsourced activities from strong foreign enterprises. Three research activities - pilot, quantitative and central qualitative - have revealed that Slovenian enterprises frequently enter outsourcing relationships without adequate strategic, long-term ...
openaire +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
La renovación del planeamiento urbanístico [PDF]
Ciudades, 2003 The real present scene of diffuse and changing cities shows the actual crisis of the traditional urban planning as a suitable instrument for the definition and control of development.
Antonio Font
doaj
Comunicação de riscos tecnológicos ambientais
Production, 1995 O crescente interesse público pelos riscos de impactos ambientais negativos provocados por resíduos industriais tornou a Comunicação de Risco um elemento decisivo no gerenciamento da atividade industrial, sendo importante o reconhecimento do contexto ...
Luiz Carlos de Martini Júnior
doaj +1 more source
FEBS Open Bio, EarlyView.Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda +12 more
wiley +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source