Results 251 to 260 of about 19,566,468 (347)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Checkpoint blockade and the stem‐like T cell trade‐off

Molecular Oncology, EarlyView.
Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley   +1 more source

The Olympic game’s up: it’s time for the IOC to stop promoting sugary drinks

BMJ Global Health
Sandra Mullin, Trish Cotter
doaj   +1 more source

Consensus Building on the Content of a Pediatric Pain Educational Program for Healthcare Professionals in a Low-Resource Setting: A Modified e-Delphi Study. [PDF]

Paediatr Neonatal Pain
Kusi Amponsah A, Badengo DB, Hammond CK, Bam V, Kyei-Dompim J, Wilson D, Armah J, Oduro E, Nawagi F, Mukherjee S, Axelin A.   +10 more
europepmc   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

RETRACTION: Effective Innovative Technologies and One Health Strategies in Mitigating Aflatoxin Contamination in Peanut Oil: A Systematic Review and Meta-Analysis. [PDF]

Food Sci Nutr
europepmc   +1 more source

Rethinking Alcohol Harm Reduction. [PDF]

Drug Alcohol Rev
Caluzzi G.
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Burnout, associated factors and coping strategies among nursing professionals in Kerala, India: a cross-sectional study. [PDF]

BMJ Open
Ambujam JK, Francis PT, Olickal JJ, Sarma PS, Thankappan KR.   +4 more
europepmc   +1 more source

Higher education institutions and the use of marketing-mix choice architecture strategies to encourage plant-rich menu options and sustainable dietary patterns: a scoping review. [PDF]

Front Nutr
Furr NL, Spence JR, Kim E, Larson-Meyer DE, Serrano E, Kraak VI.   +5 more
europepmc   +1 more source