Results 181 to 190 of about 988,232 (246)

Ready to screen implementation trial protocol: a cluster randomized implementation trial comparing a bundled implementation strategy versus a simple implementation strategy to improve intention to screen in the Australian National Lung Cancer Screening Program. [PDF]

Implement Sci
Kartal D, Paul C, Bartlett G, Abraham S, York S, Bonevski B, Emery JD, Vinod SK, Brims F, Barker D, Dodd RH, McCullough S, Tse J, Rhee J, Brooke M, May J, Norris S, Lantin MAR, Nicholls T, Marshall HM, Stone E, Onwuka S, Quaife SL, Rankin NM.   +23 more
europepmc   +1 more source

Policy, Strategy, and Practice

, 2019
openaire   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Author response to Zupan et al., Letter to the editor regarding "Intracranial hemorrhage after ischemic stroke in patients on direct oral anticoagulants: results from a prospective observational study" by Purrucker et al. [PDF]

Neurol Res Pract
Purrucker J, Haas K, Sieber M, Rücker V, Heuschmann PU, Veltkamp R.   +5 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

From classroom to community: leveraging teacher professional development research to build capacity in community-based organizations. [PDF]

Front Public Health
Kirk S, Weese M, Cruz J, Eisenkraft A, Mulhern M, Ramanadhan S.   +5 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Establishing Expert Consensus on Competencies for Safe Ward-Based Postoperative Epidural Analgesia Management: Protocol for a Modified Delphi Study. [PDF]

Acta Anaesthesiol Scand
Lamprecht CC, Bohart S, Wildgaard K, Vester-Andersen M, Mørup-Petersen A, Thomsen T.   +5 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Standardising written informed consent forms to improve patient care: a quality improvement project. [PDF]

BMJ Open Qual
Akram J, Jasim N, Al Hattab F, Khalid M, Jebril RA, Alsheikh IS, Bougaila A, Elamin NH, Subhash E, Tawengi MM, Zahid M.   +10 more
europepmc   +1 more source