Results 61 to 70 of about 18,247,458 (389)
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Economic Evaluation Method and Parameter Optimization for Third-Generation Nuclear Power in China
Zhongguo dianliAs the clean and low-carbon energy, the nuclear power has become more and more important in achieving the dual carbon target. "The economic evaluation guidelines of the nuclear power plant construction project" (NB/T 20048-2011) is the main basis for ...
Juanjuan GUO +5 more
doaj +1 more source
Big Strategy/Small Strategy [PDF]
Strategic Organization, 2012 My title plays on Rumelt’s (2011) instant classic Good Strategy/Bad Strategy. That book focuses on what works well or otherwise for organizations. Big Strategy/Small Strategy switches the focus to different issues. ‘Small Strategy’ is about financial performance, typically of firms in competitive industries.
openaire +3 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Systematic ReviewsBackground Globally, agricultural production systems consume two-thirds of all antimicrobials. These systems are used to raise animals that produce products for consumption, such as meat, eggs, milk, and wool.
Kayla Strong +6 more
doaj +1 more source
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
Decarbonizing surgical care: a qualitative systematic review guided by the Congruence Model
BMC Health Services ResearchBackground The healthcare sector must navigate the challenge of caring for individuals affected by climate change while being a significant emitter of carbon emissions. This study focuses on direct sources of carbon emissions from hospital surgical care,
Leonard Kloevekorn +4 more
doaj +1 more source
Physical Review Letters, 1999 We consider game theory from the perspective of quantum algorithms. Strategies in classical game theory are either pure (deterministic) or mixed (probabilistic). We introduce these basic ideas in the context of a simple example, closely related to the traditional Matching Pennies game.
openaire +3 more sources
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
Circulating histones as clinical biomarkers in critically ill conditions
FEBS Letters, EarlyView.Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez +17 more
wiley +1 more source