Results 111 to 120 of about 4,207,100 (284)

National Broadband Strategy 2018-2023 [PDF]

, 2018
The Government of Kenya presents the National Broadband Strategy (2023) for the country. This strategy builds on the 2013-2017 strategy and takes into account recent technological and industry trends as well as market realities. The vision of NBS 2023 is

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Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

National Tourism Strategy 2013-2018 [PDF]

, 2013
This National Tourism Strategy is a culmination of extensive stakeholder involvement and participation. It is also a fulfillment of the Tourism Act 2011, Section 3.

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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Aceptabilidad de un modelo de formulación diagnóstica de casos clínicos como estrategia educativa en una residencia de psiquiatría del niño y del adolescente

Educación Médica
Resumen: Introducción: el objetivo del estudio es analizar la aceptabilidad de un modelo de formulación diagnóstica integrativa y multidimensional, implementado como estrategia educativa en el primer año de una residencia de psiquiatría de niños y ...
Felipe Cifuentes R, Bernardo Pacheco P, Paula Bedregal, Francisca Lubi   +3 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Making sense of strategising: the process and practice of participation during strategy formulation [PDF]

Strategy As Practice (SAP) scholars have been called to explore the strategy work of individuals outside the senior leadership team as part of the “open strategy” concept.
Garlick, Ashley
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Kenya Community Health Strategy 2020-2025

, 2020
The Kenya Community Health Strategy 2020 – 2025 (KCHS 2020 – 2025) was developed to build on the Community Health Strategy 2014 – 2019. The development of the KCHS 2020 – 2025 is based on the lessons learnt from the implementation of the Community Health

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IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source