Results 111 to 120 of about 1,259,445 (289)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
FORMULATION STRATEGY UNDER THE INFLUENCE OF POWER COMPETITION [PDF]
Journal of Process Management and New Technologies, 2014 In this work, the subject of the research is defined starting hypothesis that formulation in the form of answers to the question: What factors - competitive forces shape strategy?
Ljiljana Stošić Mihajlović
doaj
Considerations regarding the Formulation of the Organisational Strategy through Simulation Techniques [PDF]
The complexity, dimension and the scope of the economic problems specific to the correct development of organisational strategie require, on the one hand, the structuring and systematisation of their entire simulation activity in view of solving them. On
Cleopatra SENDROIU +3 more
core
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Cogent Social Sciences, 2017 Strategy is distinguished as a widely discussed issue inside the scientific world. Strategic Planning constitutes an appropriate and systematic method of strategy formulation and implementation.
Athanasios Lamprou, Dimitra Vagiona
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
HOW MUCH SUCCESSFUL THE TRADITIONAL STRATEGY-MAKING MODELS IN THE CONTEMPORARY STRATEGIC ENVIRONMENT?: THE ANALYSIS OF THE ENDS, WAYS AND MEANS FORMULA [PDF]
Journal of Defense Resources Management, 2019 Strategy-making is a multi-dimensional and multi-faceted process. It encompasses interrelationships among and within parties and the strategic environment at different levels and incorporates a series of actions and reactions into a strategic plan ...
Elnur ALASGARLI
doaj
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
A model for enterprises’ environmental scanning [PDF]
Today’s environment determines companies to use scanning activities in order to seize the opportunities and to avoid the threats. Individual factors and organizational factors influence the scanning behavior.
Catalin Mihail Barbu, Tudor Nistorescu
core