Results 121 to 130 of about 1,259,445 (289)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Shakiba-Hadi Model: A New Approach forKnow ledge Strategic Formulation, Based The claims of the Islamic Republic of Iran [PDF]

مدیریت راهبردی دانش سازمانی, 2019
Principles of Strategic Strategies will be effective, regardless of the status of knowledge required, and the analysis of the knowledge gap.Adoption of the descriptive and combinational approaches to the strategic management of knowledge in the context ...
abbas chahardoli
doaj  

Analysis of the Iranian maternal mortality surveillance system and providing system improvement strategies: study protocol for strategy formulation. [PDF]

Reprod Health, 2020
Beigi M, Jahanian Sadatmahaleh S, Changizi N, Mohammadi E, Kazemi A.   +4 more
europepmc   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Aceptabilidad de un modelo de formulación diagnóstica de casos clínicos como estrategia educativa en una residencia de psiquiatría del niño y del adolescente

Educación Médica
Resumen: Introducción: el objetivo del estudio es analizar la aceptabilidad de un modelo de formulación diagnóstica integrativa y multidimensional, implementado como estrategia educativa en el primer año de una residencia de psiquiatría de niños y ...
Felipe Cifuentes R, Bernardo Pacheco P, Paula Bedregal, Francisca Lubi   +3 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Enhancing Competitive Advantage in the Disruptive Era: Strategy Formulation Framework in Model Public Junior High Schools in Indonesia

Al-Tanzim: Jurnal Manajemen Pendidikan Islam
This research aims to obtain a strategic decision framework through the strategic formulation stages as a solution to the problems found by researchers in implementing strategic formulation at Model Middle Schools in Semarang City.
Kamaludin Kamaludin, Himmah Taulany, Slamet Slamet   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

FORMULATION AND REALIZATION STRATEGY OF BUSINESS INTERNATIONALIZATION

Ekonomika Poljoprivrede (1979), 2008
Developmental behavior of a company means searching for concepts and instruments which harmonize goals and possibilities of the company with challenges and threats from surrounding.
Branko Mihailović, Zoran Simonović, Vladana Hamović   +2 more
doaj