Results 121 to 130 of about 1,242,727 (292)

Shakiba-Hadi Model: A New Approach forKnow ledge Strategic Formulation, Based The claims of the Islamic Republic of Iran [PDF]

open access: yesمدیریت راهبردی دانش سازمانی, 2019
Principles of Strategic Strategies will be effective, regardless of the status of knowledge required, and the analysis of the knowledge gap.Adoption of the descriptive and combinational approaches to the strategic management of knowledge in the context ...
abbas chahardoli
doaj  

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Enhancing Competitive Advantage in the Disruptive Era: Strategy Formulation Framework in Model Public Junior High Schools in Indonesia

open access: yesAl-Tanzim: Jurnal Manajemen Pendidikan Islam
This research aims to obtain a strategic decision framework through the strategic formulation stages as a solution to the problems found by researchers in implementing strategic formulation at Model Middle Schools in Semarang City.
Kamaludin Kamaludin   +2 more
doaj   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

open access: yesMolecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy   +9 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

open access: yesMolecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster   +3 more
wiley   +1 more source

FORMULATION AND REALIZATION STRATEGY OF BUSINESS INTERNATIONALIZATION

open access: yesEkonomika Poljoprivrede (1979), 2008
Developmental behavior of a company means searching for concepts and instruments which harmonize goals and possibilities of the company with challenges and threats from surrounding.
Branko Mihailović   +2 more
doaj  

A model for enterprises’ environmental scanning [PDF]

open access: yes
Today’s environment determines companies to use scanning activities in order to seize the opportunities and to avoid the threats. Individual factors and organizational factors influence the scanning behavior.
Catalin Mihail Barbu, Tudor Nistorescu
core  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

Computing the time-continuous Optimal Mass Transport Problem without Lagrangian techniques

open access: yes, 2009
This work originates from a heart's images tracking which is to generate an apparent continuous motion, observable through intensity variation from one starting image to an ending one both supposed segmented.
Besson, Olivier   +2 more
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

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