Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Strategy formulation as a discontinuous process
, 1976 SIGLEUuStB Koeln(38)-861100936 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische ...
Wissenschaftszentrum Berlin fuer Sozialforschung gGmbH, Berlin (Germany) +2 more
core
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Marketing strategy formulation for innovative product development process
Business: Theory and Practice, 2012 The scientific literature widely considers the new product development (NPD) process. Innovation process influencing NPD process brings for the product an exceptional value which stimulates market demand of these products.
Vaida Zemlickienė +1 more
doaj +1 more source
Groundwater well optimization to minimize contaminant movement from a surficial shallow aquifer to a lower water supply aquifer using stochastic simulation-optimization modeling techniques: Strategy formulation. [PDF]
MethodsX, 2022 Paul S +4 more
europepmc +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Formulating a Successful Management Strategy [PDF]
, 1995 “Rightsizing” is often used as a euphemism for work force reductions. In network management, “rightsizing” is not limited to the question of how an organization can do its work with fewer people. At the same time that they are being pressured to minimize the size of their organization, managers are being asked to significantly increase the scope of ...
openaire +2 more sources
IT Supporting Strategy Formulation
, 2009 This overview approaches information and communication technology (ICT) for competitive intelligence from the perspective of strategy formulation. It provides an ICT architecture for supporting the knowledge processes producing relevant knowledge for ...
Jan Achterbergh
core +1 more source