Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Prioritizing of Strategy Implementation Obstacles among Energy sector's Contractors Using Fuzzy TOPSIS Method [PDF]
Muṭāli̒āt-i Mudīriyyat-i Ṣan̒atī, 2013 The main purpose of this practical survey is devoted to identify the obstacles of strategic plan implementation among energy sector's contractors and then, to present a classification of identified obstacles on the basis of their priorities.
seyed mohammad ali khatami firouzabadi +2 more
doaj
Assessing the Europe 2020 Strategy Implementation Using Interval Entropy and Cluster Analysis for Interrelation between Two Groups of Headline Indicators. [PDF]
Entropy (Basel), 2021 Kosareva N, Krylovas A.
europepmc +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Access to HIV services and viral load suppression among children during the 90-90-90 strategy implementation in South Africa: A time series analysis. [PDF]
South Afr J HIV Med, 2021 Nyasulu JCY +3 more
europepmc +1 more source
Delivering on the PRSP in Bangladesh: An Analysis of the Implementation Challenges [PDF]
PRSP, Poverty Reduction Strategy Paper, Delivering PRSP, Implementation Challenges PRSP ...
Debapriya Bhattacharya
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
A Full Characterization of Nash Implementation with Strategy Space Reduction [PDF]
Noting that a full characterization of Nash-implementation is given using a canonical-mechanism and Maskin’s theorem (Maskin, 1999) is shown using a mechanism with Saijo’s type of strategy space reduction (Saijo, 1988), this paper fully characterizes the
Lombardi, Michele, Yoshihara, Naoki
core
Implementation of enterprise development strategy [PDF]
, 2015 Предложены методические основы преобразования стратегии развития предприятия в планы и программы, являющиеся инструментами реализации стратегии.
Kuharskaya, N. +2 more
core