Results 71 to 80 of about 7,512,964 (290)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Secure Implementation: Strategy-Proof Mechanisms Reconsidered [PDF]
Strategy-proofness, requiring that truth-telling is a dominant strategy, is a standard concept in social choice theory. However, the concept of strategy-proofness has serious drawbacks. First, announcing one's true preference may not be a unique dominant
Sjostrom, Tomas +2 more
core
An integrated approach to marketing strategy formulation and implementation [PDF]
The overall aim of the thesis was to address the issues involved in marketing strategy formulation, implementation and company performance by developing a framework for the marketing of insurance services in Jordan.
Akroush, Mamoun Nadim Awwad
core +4 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Explaining the Pattern of Effective Factors Influencing on Strategy Implementation in Organizations [PDF]
مطالعات مدیریت راهبردی, 2019 Although compiling strategies for advancing the objectives of an organization seems essential, the harmony among the organization elements for successful performance of compiled strategies is more significant; since implementing strategies in the ...
Alireza Pirali +3 more
doaj
Operational risk associated with the strategy implementation
Management, 2014 Artykuł opisuje tematykę wdrażania strategii oraz ryzyka operacyjnego, które towarzyszy temu etapowi procedury zarządzania strategicznego. Przeprowadzone badania potwierdzają istnienie zależności pomiędzy skutecznością implementacji strategii a aspektami
Radomska Joanna
doaj +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
The Involvement of Boards in Strategy Implementation [PDF]
The classical management perspective works on the assumption that CEO can design an explicit “grand strategy” for the entire enterprise. Later strategy perspectives question these normative assumptions and depict strategy as a messy, disorderly and ...
Ovidiu BORDEAN +2 more
core
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source