Results 91 to 100 of about 1,522,732 (367)

Clinical Characteristics and Prognostic Risk Factors for Pediatric B‐Cell Lymphoblastic Lymphoma: A Multicenter Retrospective Cohort Study for China Net Childhood Lymphoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background B‐cell lymphoblastic lymphoma (B‐LBL) represents a rare variety of non‐Hodgkin lymphoma, with limited research on its biology, progression, and management. Methods A retrospective analysis was performed on the clinical characteristics of 256 patients aged ≤18 years who received treatment under the China Net Childhood Lymphoma (CNCL)‐
Zhijuan Liu, Jian Wang, Ling Jin, Yanlong Duan, Fu Li, Yueping Jia, Leping Zhang, Xiaojun Yuan, Wei Liu, Ying Liu, Ansheng Liu, Mincui Zheng, Yunpeng Dai, Lian Jiang, Lirong Sun, Xiaowen Zhai, Rong Liu, Chunju Zhou, Zifen Gao, Yonghong Zhang, Xiaomei Yang   +20 more
wiley   +1 more source

Stratification Trees for Adaptive Randomization in Randomized Controlled Trials

, 2020
This paper proposes an adaptive randomization procedure for two-stage randomized controlled trials. The method uses data from a first-wave experiment in order to determine how to stratify in a second wave of the experiment, where the objective is to ...
Tabord-Meehan, Max
core  

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Accurate Diabetes Risk Stratification Using Machine Learning: Role of Missing Value and Outliers

Journal of medical systems, 2018
Diabetes mellitus is a group of metabolic diseases in which blood sugar levels are too high. About 8.8% of the world was diabetic in 2017. It is projected that this will reach nearly 10% by 2045.
M. Maniruzzaman, M. Rahman, Md. Al-MehediHasan, Harman S. Suri, M. Abedin, A. El-Baz, J. Suri   +6 more
semanticscholar   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Stratification Instability in Granular Flows

, 1998
When a mixture of two kinds of grains differing in size and shape is poured in a vertical two-dimensional cell, the mixture spontaneously stratifies in alternating layers of small and large grains, whenever the large grains are more faceted than the ...
A. Mehta, A. Rosato, E. Clément, F. Cantelaube, H. A. Makse, H. A. Makse, H. J. Herrmann, H. K. Pak, H. M. Jaeger, H. M. Jaeger, H. M. Jaeger, Hernán A. Makse, J. A. Drahun, J. B. Knight, J. C. Williams, J. C. Williams, J. Duran, J. L. Borges, J.-P. Bouchaud, J.-P. Bouchaud, O. Zik, P. Meakin, R. A. Bagnold, R. A. Bagnold, R. A. Bagnold, R. L. Brown, S. F. Edwards, S. Savage, T. Boutreux, W. Cooke   +29 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Validation of scoring system for preoperative stratification of intra-operative risks of complications during cataract surgery: Indian multi-centric study

Indian Journal of Ophthalmology, 2009
Aim: To validate a system that uniformly and objectively assesses the risk of complications of cataract surgery performed with phacoemulsification technique in individual patients preoperatively. Materials and Methods: Outcome analysis of patient data
Agrawal Vinay, Upadhyay Jinish, Indian Cataract Risk Stratification Study group   +2 more
doaj  

Stratification Economics and Identity Economics [PDF]

, 2015
Stratification economics represents an important new approach devoted to explaining economic inequality in terms of how social groups are separated or stratified along economic lines.
Davis, John B.
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source