Results 111 to 120 of about 1,337,955 (380)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

More than symbioses : orchid ecology ; with examples from the Sydney Region [PDF]

, 2013
The Orchidaceae are one of the largest and most diverse families of flowering plants. Orchids grow as terrestrial, lithophytic, epiphytic or climbing herbs but most orchids native to the Sydney Region can be placed in one of two categories.
Entwisle, Timothy J., Perkins, Andrew J., Weston, Peter H.   +2 more
core  

Fibre intake among the Belgian population by sex-age and sex-education groups and its association with BMI and waist circumference [PDF]

, 2011
The objectives of the present study were to assess total dietary fibre intake and the main contributors to fibre intake in the Belgian population by sex-age and sex-education groups and to investigate its relationship with BMI and waist circumference (WC)
Alaimo, Anja Polet, De Vriese, Fung, Guy De Backer, Herman Van Oyen, Inge Huybrechts, Janssen, John Van Camp, Koh-Banerjee, Melissa De Neve, Newby, Samra, Selin Bolca, Stefaan De Henauw, Stefanie Vandevijvere, Stephanie De Vriese, Taylor, Vandevijvere, Willem De Keyzer, Williams, Yi Lin   +21 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Cacao’s Relationship with Mesoamerican Society [PDF]

, 2013
We know what we eat, but do we eat what we know? Our diet extends far beyond nutrients and food availability—we imbue food with cultural significance. The meaning and use of a particular food is subject to change over time, but the fact that it holds a ...
Christopher, Hillary
core   +1 more source

To germinate or not to germinate : a question of dormancy relief not germination stimulation [PDF]

, 2012
A common understanding of the control of germination through dormancy is essential for effective communication between seed scientists whether they are ecologists, physiologists or molecular biologists. Vleeshouwers et al.
Batlla, Bewley, Sanchez, Steven Footitt, William E. Finch-Savage   +4 more
core   +1 more source

Polypeptide Alteration During The Cold Stratification In Mazzard Seed

Erwerbs-Obstbau, 2017
Many seeds of woody plants require low temperature for germination and that’s called seed dormancy has been investigated for relations of proteins by several researchers. We determined polypeptide profiles of cold-stratified Mazzard seeds. Seeds were studied in five different periods: seeds in dormancy (none stratified), 30, 60, 90 and 120 days cold ...
Aras, Servet, Arslan, Emine, Esitken, Ahmet, Kilic, Merve   +3 more
openaire   +3 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source