Results 211 to 220 of about 1,337,955 (380)

Long‐Term Active Rather than Passive Restoration Promotes Soil Organic Carbon Accumulation by Alleviating Microbial Nitrogen Limitation in an Extremely Degraded Alpine Grassland

open access: yesAdvanced Science, EarlyView.
Active restoration increases soil organic carbon stocks by reducing microbial nitrogen limitation. Nitrogen availability promotes particulate to mineral‐associated organic carbon conversion by reducing microbial carbon use efficiency. Passive restoration has no effect on soil organic carbon stocks.
Jinchao Gong   +15 more
wiley   +1 more source

Stratification of Brain-Derived Extracellular Vesicles of Alzheimer’s Disease Patients Indicates a Unique Proteomic Content and a Higher Seeding Capacity of Small Extracellular Vesicles

open access: gold
Marie Oosterlynck   +13 more
openalex   +1 more source

ACSL5 Regulates Glucose Metabolism and Chemotherapy Sensitivity in Colorectal Cancer Cells under Glutamine Deficiency

open access: yesAdvanced Science, EarlyView.
Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian   +11 more
wiley   +1 more source

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

open access: yesAdvanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong   +6 more
wiley   +1 more source

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