Results 291 to 300 of about 1,337,955 (380)

Acetylation Regulates ACSL4 Degradation Through Chaperone‐Mediated Autophagy to Alleviate Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Intervertebral disc degeneration is triggered by ACSL4 accumulation‐mediated ferroptosis of nucleus pulposus cells due to CMA dysfunction. KAT2B promotes ACSL4 degradation via CMA through acetylation. AAV‐mediated LAMP2A delivery or engineered exosomes rescue nucleus pulposus cell senescence and disc degeneration.
Zhouwei Wu, Zhichen Jiang, Chenglong Hong, Shu Yang, Shuqing Jin, Chenyu Wu, Kaijie Guo, Jiang Liu, Shaobo Xu, Chenggui Wang, Xiangyang Wang   +10 more
wiley   +1 more source

Seed biology and regeneration niche of the threatened cold desert perennial <i>Ivesia webberi</i> A. Gray. [PDF]

Front Plant Sci
Borokini IT, France MD, Harmon D, Shoemaker KT, Weisberg PJ, Peacock MM.   +5 more
europepmc   +1 more source

S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning

Advanced Science, EarlyView.
Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu, Penglei Wang, Gaoyuan Xu, Jitao Lu, Qinke Peng, Danyang Wu, Hequan Sun   +6 more
wiley   +1 more source

In Vitro Seed Germination, Seedling Development, Multiple Shoot Induction and Rooting of <i>Actinidia chinensis</i>. [PDF]

Plants (Basel)
Sekhukhune MK, Maila YM.
europepmc   +1 more source

Targeting the GPX4–FUNDC1 Interaction with Magnesium Lithospermate B Attenuates Sepsis‐Associated Lung Injury

Advanced Science, EarlyView.
The diagram depicts the endothelial‐protective mechanism of magnesium lithospermate B (MLB) in sepsis‐associated lung injury. MLB binds GPX4 at Gly79, disrupts its interaction with FUNDC1, prevents mitophagy‐mediated GPX4 degradation, restores mitophagic flux, reduces ROS, and limits ferroptosis.
Zhixi Li, Chang Liu, Zhaoxue Ma, Dongyou Zheng, Renkai Wang, Yongjing Yu, Guangmin Chen, Chenglong Li, Yue Bu, Hang Cao, Bing Zhang   +10 more
wiley   +1 more source

Tuber mustard BjuFIP gene negatively regulates plant sensitivity to abscisic acid. [PDF]

Sci Rep
Cai Z, Shi N, Chang Y, Liu S, Wang D, Cheng C.   +5 more
europepmc   +1 more source

Additional file 3 of Stratification of brain-derived extracellular vesicles of Alzheimer’s disease patients indicates a unique proteomic content and a higher seeding capacity of small extracellular vesicles

Oosterlynck, Marie, Leroux, Elodie, Namasivayam, Balasubramaniam, Bouillet, Thomas, Caillierez, Raphaelle, Loyens, Anne, Mazur, Daniele, Perbet, Romain, Lefebvre, Christophe, Aboulouard, Soulaimane, Maurage, Claude-Alain, Accart, Bertrand, Buée, Luc, Colin, Morvane   +13 more
openalex   +1 more source

From Natural Discovery to AI‐Guided Design: A Curated Collection of Compact Enhancers for Crop Engineering

Advanced Science, EarlyView.
ABSTRACT Precise transgene‐free gene upregulation remains a challenge in crop biotechnology, as conventional enhancers often exceed CRISPR‐mediated knock‐in size constraints and face regulatory hurdles. Here we establish a foundational cross‐species resource of compact transcriptional enhancers developed via STEM‐seq, a high‐throughput screening ...
Qi Yao, Jin Gao, Keling Wang, Yufeng Liu, Peijin Han, Hong Pan, Xiaofeng Yang, Qianlan Yin, Dating Zhong, Lu Ye, Qi Deng, Lingling Gao, Xiaoyu Tu, Dequan Wang, Yuming Lu   +14 more
wiley   +1 more source

Complex Seed Dormancy in Parrotia subaequalis: Identification, Breaking Mechanisms, and Conservation Strategies for an Endangered Species in China. [PDF]

Plants (Basel)
Yang Y, Luo L, Zhu L, Cheng Y, Yuan M, Ruan X, Zhao K.   +6 more
europepmc   +1 more source

Nanodiamond Regulated Electrolyte Enhances Thermal, Chemical and Structural Properties for Highly Reversible Zn Metal Anodes

Advanced Science, EarlyView.
Nanodiamond additives are dispersed in the aqueous electrolyte to organize water molecules, suppress gas evolution and metal corrosion, and guide zinc to deposit more uniformly. Together with enhanced thermal conductivity for fast heat removal, this strategy reduces temperature rise and degradation, enabling safer, more durable rechargeable zinc metal ...
Jiayan Zhu, Xuan Gao, Nan Gao, Shaoheng Cheng, Junsong Liu, Yuhang Dai, Zhengxiao Guo, Hongdong Li   +7 more
wiley   +1 more source