Results 121 to 130 of about 5,682,532 (321)

Are we giving stratified care a fair trial?

Journal of Physiotherapy, 2023
N. Foster, Jonathan C Hill, J. Knoop
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Cardiovascular disease morbidity is associated with social deprivation in subjects with familial hypercholesterolaemia (FH): a study comparing FH individuals in UK primary care and the UK Simon Broome register linked with secondary care records

Atherosclerosis Plus, 2022
B. Iyen, N. Qureshi, P. Roderick, N. Capps, P.N. Durrington, I.F.W. McDowell, J. Cegla, H. Soran, J. Schofield, H.A.W. Neil, J. Kai, S. Weng, S.E. Humphries   +12 more
doaj   +1 more source

Stratified membership: health care access for urban refugees in Turkey

Comparative Migration Studies, 2019
Turkey hosts more refugees than any other country in the world. Incoming numbers have increased steadily since the outbreak of the Syrian war in 2011.
Wanda Spahl, August Österle
doaj   +1 more source

Trends and Racial/Ethnic Differences in Health Care Spending Stratified by Gender among Adults with Arthritis in the United States 2011–2019 [PDF]

, 2022
Antoinette L. Spector, Emily Matsen, Leonard E. Egede   +2 more
openalex   +1 more source

Burden and Depression among Caregivers of Visually Impaired Patients in a Canadian Population [PDF]

, 2016
Purpose/Background. This study reports the degree of burden and the proportion at risk for depression among individuals who provide care to visually impaired patients. Study Design. This is clinic-based, cross-sectional survey in a tertiary care hospital.
Almeida, David, Braich, Puneet S., Iqbal, Munir, Khan, Zainab, Mohamed, Karim, Rahim, Karim, Rayat, Jaspreet S., Sharma, Sanjay, Xing, Lin   +8 more
core   +5 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Reduction in cardiovascular disease morbidity of men and women with familial hypercholesterolaemia (FH) associated with availability of high intensity statins: A cohort study using data from the UK Simon Broome Register linked with secondary care records

Atherosclerosis Plus, 2021
B. Iyen, N. Qureshi, P. Roderick, N. Capps, P.N. Durrington, I.F.W. McDowell, J. Cegla, H. Soran, J. Schofield, H.A.W. Neil, J. Kai, S. Weng, S.E. Humphries   +12 more
doaj   +1 more source

Lost in implementation: risk stratified care for musculoskeletal pain. [PDF]

Pain, 2023
George SZ.
europepmc   +1 more source

Management and Care of Women With Invasive Cervical Cancer: American Society of Clinical Oncology Resource-Stratified Clinical Practice Guideline

Journal of Global Oncology, 2016
Purpose To provide evidence-based, resource-stratified global recommendations to clinicians and policymakers on the management and palliative care of women diagnosed with invasive cervical cancer.
L. Chuang, S. Temin, R. Camacho, A. Dueñas-González, S. Feldman, M. Gultekin, Vandana Gupta, S. Horton, G. Jacob, E. Kidd, K. Lishimpi, Carolyn Nakisige, J. Nam, H. Ngan, W. Small, G. Thomas, J. Berek   +16 more
semanticscholar   +1 more source