Results 41 to 50 of about 30,159 (217)

The clinical and cost-effectiveness of stratified care for patients with sciatica: the SCOPiC randomised controlled trial protocol (ISRCTN75449581)

open access: yesBMC Musculoskeletal Disorders, 2017
Background Sciatica has a substantial impact on patients, and is associated with high healthcare and societal costs. Although there is variation in the clinical management of sciatica, the current model of care usually involves an initial period of ‘wait
Nadine E. Foster   +14 more
doaj   +1 more source

Applications of Machine Learning to the Identification of Anomalous ER Claims [PDF]

open access: yesarXiv, 2022
Improper health insurance payments resulting from fraud and upcoding result in tens of billions of dollars in excess health care costs annually in the United States, motivating machine learning researchers to build anomaly detection models for health insurance claims. This article describes two such strategies specifically for ER claims.
arxiv  

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

open access: yesMolecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever   +1 more
wiley   +1 more source

Depression, anxiety and suicidal behaviour among college students: Comparisons pre-COVID-19 and during the pandemic

open access: yesPsychiatry Research Communications, 2021
Background: Many students struggle with psychological problems during their college years. These problems may be even more apparent during the COVID-19 pandemic with the accompanying restrictions and transition to an online learning environment, but few ...
Margaret McLafferty   +10 more
doaj  

Is the apparently protective effect of maternal nicotine replacement therapy (NRT) used in pregnancy on infant development explained by smoking cessation?: secondary analyses of a randomised controlled trial

open access: yesBMJ Open, 2019
Objective To investigate relationships between maternal smoking status in pregnancy and infant development. The largest randomised controlled trial of nicotine replacement therapy (NRT) for smoking cessation in pregnancy, the smoking, nicotine and ...
Sarah Lewis   +5 more
doaj   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

open access: yesMolecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker   +14 more
wiley   +1 more source

TACE/ADAM17 substrates associate with ACS (Ep-CAM, HB-EGF) and follow-up MACE (TNFR1 and TNFR2)

open access: yesAtherosclerosis Plus, 2022
Background and aims: TACE/ADAM17 is a membrane bound metalloprotease, which cleaves substrates involved in immune and inflammatory responses and plays a role in coronary artery disease (CAD).
Melody Chemaly   +7 more
doaj  

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

open access: yesMolecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen   +13 more
wiley   +1 more source

Effectiveness and Cost-Effectiveness of a Stratified Blended Physiotherapy Intervention Compared With Face-to-Face Physiotherapy in Patients With Nonspecific Low Back Pain: Cluster Randomized Controlled Trial

open access: yesJournal of Medical Internet Research, 2023
BackgroundNonspecific low back pain (LBP) is a leading contributor to disability worldwide, and its socioeconomic burden is substantial.
Tjarco Koppenaal   +6 more
doaj   +1 more source

Asymptotic behavior of 2D stably stratified fluids with a damping term in the velocity equation [PDF]

open access: yesESAIM: Control, Optimisation and Calculus of Variations 2021, 2020
This article is concerned with the asymptotic behavior of the two-dimensional inviscid Boussinesq equations with a damping term in the velocity equation. Precisely, we provide the time-decay rates of the smooth solutions to that system. The key ingredient is a careful analysis of the Green kernel of the linearized problem in Fourier space, combined ...
arxiv  

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