Results 21 to 30 of about 532,019 (236)

Effectiveness of stratified treatment for back pain in Danish primary care: A randomized controlled trial [PDF]

, 2021
Background A randomized controlled trial (RCT) of stratified care demonstrated superior clinical outcomes and cost-effectiveness for low back pain (LBP) patients in UK primary care.
Lars Morsø, Schiøttz-Christensen, Berit; id_orcid, Kim Olsen Rose, Berit Schiøttz‐Christensen, Jens Søndergaard, David H. Christiansen, Morsø, Lars; id_orcid, Olsen Rose, Kim; id_orcid, Christiansen, David H., Gail Sowden, Søndergaard, Jens; id_orcid, Sowden, Gail   +11 more
core   +3 more sources

Performance and clinical utility of supervised machine-learning approaches in detecting familial hypercholesterolaemia in primary care

npj Digital Medicine, 2020
Familial hypercholesterolaemia (FH) is a common inherited disorder, causing lifelong elevated low-density lipoprotein cholesterol (LDL-C). Most individuals with FH remain undiagnosed, precluding opportunities to prevent premature heart disease and death.
Ralph K. Akyea, Nadeem Qureshi, Joe Kai, Stephen F. Weng   +3 more
doaj   +1 more source

Evaluating a clinical tool (FAMCAT) for identifying familial hypercholesterolaemia in primary care: a retrospective cohort study

BJGP Open, 2020
Background: Familial hypercholesterolaemia (FH) is an inherited lipid disorder causing premature heart disease, which is severely underdiagnosed. Improving the identification of people with FH in primary care settings would help to reduce avoidable heart
Ralph K Akyea, Nadeem Qureshi, Joe Kai, Simon de Lusignan, Julian Sherlock, Christopher McGee, Stephen Weng   +6 more
doaj   +1 more source

The Interdependency and Co-Regulation of the Vitamin D and Cholesterol Metabolism

Cells, 2021
Vitamin D and cholesterol metabolism overlap significantly in the pathways that contribute to their biosynthesis. However, our understanding of their independent and co-regulation is limited.
Tara Warren, Roisin McAllister, Amy Morgan, Taranjit Singh Rai, Victoria McGilligan, Matthew Ennis, Christopher Page, Catriona Kelly, Aaron Peace, Bernard M. Corfe, Mark Mc Auley, Steven Watterson   +11 more
doaj   +1 more source

Statin treatment and LDL-cholesterol treatment goal attainment among individuals with familial hypercholesterolaemia in primary care

Open Heart, 2021
Objectives Guidance recommends statin treatment in familial hypercholesterolaemia (FH) to achieve at least a 50% reduction in low-density lipoprotein cholesterol (LDL-C).
Joe Kai, Nadeem Qureshi, Barbara Iyen, Stephen Weng, Ralph K Akyea   +4 more
doaj   +1 more source

The impact of hearing impairment and hearing aid use on progression to mild cognitive impairment in cognitively healthy adults: An observational cohort study

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022
Introduction We assessed the association of self‐reported hearing impairment and hearing aid use with cognitive decline and progression to mild cognitive impairment (MCI).
Magda Bucholc, Sarah Bauermeister, Daman Kaur, Paula L. McClean, Stephen Todd   +4 more
doaj   +1 more source

TACE/ADAM17 substrates associate with ACS (Ep-CAM, HB-EGF) and follow-up MACE (TNFR1 and TNFR2)

Atherosclerosis Plus, 2022
Background and aims: TACE/ADAM17 is a membrane bound metalloprotease, which cleaves substrates involved in immune and inflammatory responses and plays a role in coronary artery disease (CAD).
Melody Chemaly, Roisin McAllister, Aaron Peace, Anthony John Bjourson, Steve Watterson, Andrew Parton, Matthias Clauss, Victoria McGilligan   +7 more
doaj   +1 more source

The Finnish therapy navigator – Digital support system for introducing stepped care in Finland [PDF]

Psychiatria Fennica, 2022
Introduction: The need to improve quick access to effective psychological treatments is urgent. Success requires effective tools for identifying what kind of therapies an individual is likely to benefit from and managing a comprehensive therapy offering
Samuli I. Saarni, Sara Nurminen, Kasperi Mikkonen, Helena Service, Tino Karolaakso, Jan-Henry Stenberg, Jesper Ekelund, Suoma E. Saarni   +7 more
doaj  

Depression, anxiety and suicidal behaviour among college students: Comparisons pre-COVID-19 and during the pandemic

Psychiatry Research Communications, 2021
Background: Many students struggle with psychological problems during their college years. These problems may be even more apparent during the COVID-19 pandemic with the accompanying restrictions and transition to an online learning environment, but few ...
Margaret McLafferty, Natasha Brown, Rachel McHugh, Caoimhe Ward, Ailis Stevenson, Louise McBride, John Brady, Anthony J. Bjourson, Siobhan M. O'Neill, Colum P. Walsh, Elaine K. Murray   +10 more
doaj   +1 more source

Detection of familial hypercholesterolaemia: external validation of the FAMCAT clinical case-finding algorithm to identify patients in primary care

The Lancet Public Health, 2019
Summary: Background: The vast majority of individuals with familial hypercholesterolaemia in the general population remain unidentified worldwide. Recognising patients most likely to have the condition, to enable targeted specialist assessment and ...
Stephen Weng, PhD, Joe Kai, ProfMD, Ralph Akyea, MPH, Nadeem Qureshi, ProfDM   +3 more
doaj   +1 more source