Results 41 to 50 of about 532,019 (236)

Formulating RALA/Au nanocomplexes to enhance nanoparticle internalisation efficiency, sensitising prostate tumour models to radiation treatment

Journal of Nanobiotechnology, 2021
Background Gold nanoparticles (AuNP) are effective radiosensitisers, however, successful clinical translation has been impeded by short systemic circulation times and poor internalisation efficiency.
Lindsey A. Bennie, Jie Feng, Christopher Emmerson, Wendy B. Hyland, Kyle B. Matchett, Helen O. McCarthy, Jonathan A. Coulter   +6 more
doaj   +1 more source

Opportunities and challenges for enhancing preconception health in primary care: qualitative study with women from ethnically diverse communities

BMJ Open, 2013
Objective  There is a growing interest in developing and offering more systematic preconception healthcare. However, it is unclear how this might be regarded by ethnically diverse communities at higher risk of poor maternal and child health outcomes.
Joe Kai, Nadeem Qureshi, Helena Tuomainen, Laura Cross-Bardell, Mandeep Bhoday   +4 more
doaj   +1 more source

A Systematic Approach to Review of in vitro Methods in Brain Tumour Research (SAToRI-BTR): Development of a Preliminary Checklist for Evaluating Quality and Human Relevance

Frontiers in Bioengineering and Biotechnology, 2020
BackgroundA wide range of human in vitro methods have been developed and there is considerable interest in the potential of these studies to address questions related to clinical (human) use of drugs, and the pathobiology of tumours.
Mike Bracher, Geoffrey J. Pilkington, C. Oliver Hanemann, Karen Pilkington   +3 more
doaj   +1 more source

Development and feasibility of stratified primary care physiotherapy integrated with eHealth in patients with neck and/or shoulder complaints: results of a mixed methods study [PDF]

, 2023
BACKGROUND: Providing individualized care based on the context and preferences of the patient is important. Knowledge on both prognostic risk stratification and blended eHealth care in musculoskeletal conditions is increasing and seems promising ...
Staal, Bart, Tilburg,van, Mark, Foster, Nadine E, Ostelo, Raymond W J G, Kloek, Corelien J. J., Ostelo, Raymond W.J.G.; id_orcid, Foster, Nadine, Pisters, Martijn F., Staal, J Bart, Staal, J. Bart, Pisters, Martijn F, Ostelo, Raymond W. J. G., Ostelo, Raymond W.J.G., Veenhof, Cindy, van Tilburg, Mark L, Ostelo, Raymond, Pisters, Martijn, van Tilburg, Mark L., Kloek, Corelien, Kloek, Corelien J J, Foster, Nadine E., Kloek, Corelien J.J.   +21 more
core   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

The effects of designation and volume of neonatal care on mortality and morbidity outcomes of very preterm infants in England : retrospective population-based cohort study [PDF]

, 2014
Objective: To examine the effects of designation and volume of neonatal care at the hospital of birth on mortality and morbidity outcomes in very preterm infants in a managed clinical network setting.
Draper, E S, Petrou, Stavros, Marlow, N, Marlow, Neil, Arulampalam, Wiji, Morgan, A. S., W. Arulampalam (7661012), Modi, N., S. Santhakumaran (7682309), Draper, Elizabeth S., Draper, ES, Elizabeth S. Draper (7243004), Morgan, AS, Santhakumaran, S, S. Petrou (7627187), Petrou, S, A. S. Morgan (7661015), Neonatal Data Analysis Unit and the NESCOP Group (7682312), S. I. Watson (7661009), Modi, N, N. Modi (7625024), Watson, Samuel I., Arulampalam, W, N. Marlow (7608419), Santhakumaran, S., Watson, SI, Watson, S I, Morgan, A S   +27 more
core   +1 more source

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Risk-stratified and stepped models of care for back pain and osteoarthritis: are we heading towards a common model? [PDF]

, 2020
The overall quality of care for musculoskeletal pain conditions is suboptimal, partly due to a considerable evidence-practice gap. In osteoarthritis and low back pain, structured models of care exist to help overcome that challenge.
Hill, Jonathan
core   +1 more source

Is the apparently protective effect of maternal nicotine replacement therapy (NRT) used in pregnancy on infant development explained by smoking cessation?: secondary analyses of a randomised controlled trial

BMJ Open, 2019
Objective To investigate relationships between maternal smoking status in pregnancy and infant development. The largest randomised controlled trial of nicotine replacement therapy (NRT) for smoking cessation in pregnancy, the smoking, nicotine and ...
Sarah Lewis, Tim Coleman, Barbara Iyen, Luis R Vaz, Jaspal Taggar, Sue Cooper   +5 more
doaj   +1 more source