Results 11 to 20 of about 4,841,074 (245)

Comparing the performance of the novel FAMCAT algorithms and established case-finding criteria for familial hypercholesterolaemia in primary care

Open Heart, 2021
Objective Familial hypercholesterolaemia (FH) is a common inherited disorder causing premature coronary heart disease (CHD) and death. We have developed the novel Familial Hypercholesterolaemia Case Ascertainment Tool (FAMCAT 1) case-finding algorithm ...
Joe Kai, Nadeem Qureshi, Stephen Weng, Ralph K Akyea, Jo Leonardi-Bee, Steve E Humphries, Brittany Dutton   +6 more
doaj   +1 more source

Obesity and long‐term outcomes after incident stroke: a prospective population‐based cohort study

Journal of Cachexia, Sarcopenia and Muscle, 2021
Background The association between obesity, major adverse cardiovascular events (MACE), and mortality in patients with incident stroke is not well established.
Ralph K. Akyea, Wolfram Doehner, Barbara Iyen, Stephen F. Weng, Nadeem Qureshi, George Ntaios   +5 more
doaj   +1 more source

Multipronged Programmatic Strategy for Preventing Secondary Fracture and Facilitating Functional Recovery in Older Patients after Hip Fractures: Our Experience in Taipei Municipal Wanfang Hospital

Medicina, 2022
Background and Objectives: The study assessed the effectiveness of a fracture liaison service (FLS) after 1 year of implementation in improving the outcomes of hip fracture surgery in older adult patients at Taipei Municipal Wanfang Hospital.
Yu-Pin Chen, Wei-Chun Chang, Tsai-Wei Wen, Pei-Chun Chien, Shu-Wei Huang, Yi-Jie Kuo   +5 more
doaj   +1 more source

Performance and clinical utility of supervised machine-learning approaches in detecting familial hypercholesterolaemia in primary care

npj Digital Medicine, 2020
Familial hypercholesterolaemia (FH) is a common inherited disorder, causing lifelong elevated low-density lipoprotein cholesterol (LDL-C). Most individuals with FH remain undiagnosed, precluding opportunities to prevent premature heart disease and death.
Ralph K. Akyea, Nadeem Qureshi, Joe Kai, Stephen F. Weng   +3 more
doaj   +1 more source

Evaluating a clinical tool (FAMCAT) for identifying familial hypercholesterolaemia in primary care: a retrospective cohort study

BJGP Open, 2020
Background: Familial hypercholesterolaemia (FH) is an inherited lipid disorder causing premature heart disease, which is severely underdiagnosed. Improving the identification of people with FH in primary care settings would help to reduce avoidable heart
Ralph K Akyea, Nadeem Qureshi, Joe Kai, Simon de Lusignan, Julian Sherlock, Christopher McGee, Stephen Weng   +6 more
doaj   +1 more source

The Interdependency and Co-Regulation of the Vitamin D and Cholesterol Metabolism

Cells, 2021
Vitamin D and cholesterol metabolism overlap significantly in the pathways that contribute to their biosynthesis. However, our understanding of their independent and co-regulation is limited.
Tara Warren, Roisin McAllister, Amy Morgan, Taranjit Singh Rai, Victoria McGilligan, Matthew Ennis, Christopher Page, Catriona Kelly, Aaron Peace, Bernard M. Corfe, Mark Mc Auley, Steven Watterson   +11 more
doaj   +1 more source

Statin treatment and LDL-cholesterol treatment goal attainment among individuals with familial hypercholesterolaemia in primary care

Open Heart, 2021
Objectives Guidance recommends statin treatment in familial hypercholesterolaemia (FH) to achieve at least a 50% reduction in low-density lipoprotein cholesterol (LDL-C).
Joe Kai, Nadeem Qureshi, Barbara Iyen, Stephen Weng, Ralph K Akyea   +4 more
doaj   +1 more source

The impact of hearing impairment and hearing aid use on progression to mild cognitive impairment in cognitively healthy adults: An observational cohort study

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022
Introduction We assessed the association of self‐reported hearing impairment and hearing aid use with cognitive decline and progression to mild cognitive impairment (MCI).
Magda Bucholc, Sarah Bauermeister, Daman Kaur, Paula L. McClean, Stephen Todd   +4 more
doaj   +1 more source

TACE/ADAM17 substrates associate with ACS (Ep-CAM, HB-EGF) and follow-up MACE (TNFR1 and TNFR2)

Atherosclerosis Plus, 2022
Background and aims: TACE/ADAM17 is a membrane bound metalloprotease, which cleaves substrates involved in immune and inflammatory responses and plays a role in coronary artery disease (CAD).
Melody Chemaly, Roisin McAllister, Aaron Peace, Anthony John Bjourson, Steve Watterson, Andrew Parton, Matthias Clauss, Victoria McGilligan   +7 more
doaj   +1 more source

The Finnish therapy navigator – Digital support system for introducing stepped care in Finland [PDF]

Psychiatria Fennica, 2022
Introduction: The need to improve quick access to effective psychological treatments is urgent. Success requires effective tools for identifying what kind of therapies an individual is likely to benefit from and managing a comprehensive therapy offering
Samuli I. Saarni, Sara Nurminen, Kasperi Mikkonen, Helena Service, Tino Karolaakso, Jan-Henry Stenberg, Jesper Ekelund, Suoma E. Saarni   +7 more
doaj