Results 51 to 60 of about 5,374,450 (272)

Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines

Frontiers in Immunology, 2018
Cytokine dysregulation is believed to play a key role in the remodeling of the immune system at older age, with evidence pointing to an inability to fine-control systemic inflammation, which seems to be a marker of unsuccessful aging.
Irene Maeve Rea, Irene Maeve Rea, Irene Maeve Rea, David S. Gibson, Victoria McGilligan, Susan E. McNerlan, H. Denis Alexander, Owen A. Ross, Owen A. Ross, Owen A. Ross   +9 more
doaj   +1 more source

Formulating RALA/Au nanocomplexes to enhance nanoparticle internalisation efficiency, sensitising prostate tumour models to radiation treatment

Journal of Nanobiotechnology, 2021
Background Gold nanoparticles (AuNP) are effective radiosensitisers, however, successful clinical translation has been impeded by short systemic circulation times and poor internalisation efficiency.
Lindsey A. Bennie, Jie Feng, Christopher Emmerson, Wendy B. Hyland, Kyle B. Matchett, Helen O. McCarthy, Jonathan A. Coulter   +6 more
doaj   +1 more source

Opportunities and challenges for enhancing preconception health in primary care: qualitative study with women from ethnically diverse communities

BMJ Open, 2013
Objective  There is a growing interest in developing and offering more systematic preconception healthcare. However, it is unclear how this might be regarded by ethnically diverse communities at higher risk of poor maternal and child health outcomes.
Joe Kai, Nadeem Qureshi, Helena Tuomainen, Laura Cross-Bardell, Mandeep Bhoday   +4 more
doaj   +1 more source

A Systematic Approach to Review of in vitro Methods in Brain Tumour Research (SAToRI-BTR): Development of a Preliminary Checklist for Evaluating Quality and Human Relevance

Frontiers in Bioengineering and Biotechnology, 2020
BackgroundA wide range of human in vitro methods have been developed and there is considerable interest in the potential of these studies to address questions related to clinical (human) use of drugs, and the pathobiology of tumours.
Mike Bracher, Geoffrey J. Pilkington, C. Oliver Hanemann, Karen Pilkington   +3 more
doaj   +1 more source

A Quality Improvement Initiative to Standardize Pneumocystis jirovecii Pneumonia Prophylaxis in Pediatric Patients With Solid Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric patients with extracranial solid tumors (ST) receiving chemotherapy are at an increased risk for Pneumocystis jirovecii pneumonia (PJP). However, evidence guiding prophylaxis practices in this population is limited. A PJP‐related fatality at our institution highlighted inconsistent prescribing approaches and concerns about
Kriti Kumar, Denise M. Connolly, Ellen Kellington, Elyse Zelunka, Karla Kerrigan, Furqan Shaikh, Paul C. Nathan, Meredith S. Irwin, Sarah Cohen‐Gogo   +8 more
wiley   +1 more source

Stratified primary care for adults with musculoskeletal pain: the STarT MSK research programme including RCTs

Programme Grants for Applied Research, 2023
Background Usual primary care for patients with musculoskeletal pain varies widely and treatment outcomes are suboptimal. Stratified care involves targeting treatments according to patient subgroups, in the hope of maximising treatment benefit and ...
Foster Nadine E, Dunn Kate M, Protheroe Joanne, Hill Jonathan C, Lewis Martyn, Saunders Benjamin, Jowett Sue, Hennings Susie, Campbell Paul, Bromley Kieran, Bartlam Bernadette, Babatunde Opeyemi, Wathall Simon, Oppong Raymond, Kigozi Jesse, Chudyk Adrian   +15 more
doaj   +1 more source

Sickle Cell Disease Is an Inherent Risk for Asthma in a Sibling Comparison Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Sickle cell disease (SCD) and asthma share a complex relationship. Although estimates vary, asthma prevalence in children with SCD is believed to be comparable to or higher than the general population. Determining whether SCD confers an increased risk for asthma remains challenging due to overlapping symptoms and the ...
Suhei C. Zuleta De Bernardis, Okeleji Olayinka, Mariam Z. Quraishi, Lakshmi V. Srivaths, Deborah L. Brown, Neethu M. Menon, Ricardo A. Mosquera, Ashwin P. Patel, James M. Stark, Aravind Yadav   +9 more
wiley   +1 more source

Patients’ and physiotherapists’ perspectives on implementing a tailored stratified treatment approach for low back pain in Nigeria: a qualitative study

BMJ Open, 2022
Background Stratified care has the potential to be efficient in addressing the physical and psychosocial components of low back pain (LBP) and optimise treatment outcomes essential in low-income countries.
Kay Stevenson, Mishael Adje, Jost Steinhäuser, Chidozie Emmanuel Mbada, Sven Karstens   +4 more
doaj   +1 more source

The central role of provider training in implementing resource‐stratified guidelines for palliative care in low‐income and middle‐income countries: Lessons from the Jamaica Cancer Care and Research Institute in the Caribbean and Universidad Católica in Latin America

Cancer, 2020
Individuals in low‐income and middle‐income countries (LMICs) account for approximately two‐thirds of cancer deaths worldwide, and the vast majority of these deaths occur without access to essential palliative care (PC).
Mark Stoltenberg, D. Spence, B. Daubman, N. Greaves, R. Edwards, Brittany Bromfield, P. Perez-Cruz, E. Krakauer, M. Argentieri, Alexandra E. Shields   +9 more
semanticscholar   +1 more source

Potential Early Risk Biomarkers for Reduced Forced Expiratory Volume in Children Post‐Hematopoietic Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We sought to identify potential early risk biomarkers for lung disease in children post‐allogeneic HCT. Patients with pulmonary function tests 3 months post‐transplant and plasma samples between days 7 and 14 post‐HCT were included. Six of 27 subjects enrolled had reduced forced expiratory volume 1 (FEV1) z scores.
Isabella S. Small, Pi Chun Cheng, April L. Rahrig, Courtney M. Rowan   +3 more
wiley   +1 more source