Results 51 to 60 of about 30,159 (217)
The Lancet Public Health, 2019 Summary: Background: The vast majority of individuals with familial hypercholesterolaemia in the general population remain unidentified worldwide. Recognising patients most likely to have the condition, to enable targeted specialist assessment and ...
Stephen Weng, PhD +3 more
doaj
Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients
Molecular Oncology, EarlyView.Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha +6 more
wiley +1 more source
Journal of Spine Practice, 2021 Introduction: Research evidence suggests that a stratified care management approach is better at improving clinical and economic outcomes for low back pain (LBP) patients compared with usual care in the short term. However, it is unclear if these health
Collins Ogbeivor
doaj +1 more source
The contact mappings of a flat $(2,3,5)$-distribution [PDF]
arXiv, 2020 Let $\Omega$ and $\Omega'$ be open subsets of a flat $(2,3,5)$-distribution. We show that a $C^1$-smooth contact mapping $f : \Omega \to \Omega'$ is a $C^\infty$-smooth contact mapping. Ultimately, this is a consequence of the rigidity of the associated stratified Lie group (the Tanaka prolongation of the Lie algebra is of finite-type).
arxiv
Molecular Oncology, EarlyView.The LEXOVE prospective study evaluated plasma cell‐free extracellular vesicle (cfEV) dynamics using Bradford assay and dynamic light scattering in metastatic non‐small cell lung cancer patients undergoing first‐line treatments, correlating a ∆cfEV < 20% with improved median progression‐free survival in responders versus non‐responders.
Valerio Gristina +17 more
wiley +1 more source
BMC Musculoskeletal Disorders, 2021 Background Neck and shoulder complaints are common in primary care physiotherapy. These patients experience pain and disability, resulting in high societal costs due to, for example, healthcare use and work absence. Content and intensity of physiotherapy
Mark L. van Tilburg +8 more
doaj +1 more source
Molecular Oncology, EarlyView.We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić +31 more
wiley +1 more source
Molecular Oncology, EarlyView.Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale +9 more
wiley +1 more source
A radiation condition for the 2-D Helmholtz equation in stratified media [PDF]
arXiv, 2009 We study the 2-D Helmholtz equation in perturbed stratified media, allowing the existence of guided waves. Our assumptions on the perturbing and source terms are not too restrictive. We prove two results. Firstly, we introduce a Sommerfeld-Rellich radiation condition and prove the uniqueness of the solution for the studied equation.
arxiv
Molecular Oncology, EarlyView.The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld +7 more
wiley +1 more source