Results 71 to 80 of about 5,682,532 (321)

Stratified primary care for adults with musculoskeletal pain: the STarT MSK research programme including RCTs

Programme Grants for Applied Research, 2023
Background Usual primary care for patients with musculoskeletal pain varies widely and treatment outcomes are suboptimal. Stratified care involves targeting treatments according to patient subgroups, in the hope of maximising treatment benefit and ...
Foster Nadine E, Dunn Kate M, Protheroe Joanne, Hill Jonathan C, Lewis Martyn, Saunders Benjamin, Jowett Sue, Hennings Susie, Campbell Paul, Bromley Kieran, Bartlam Bernadette, Babatunde Opeyemi, Wathall Simon, Oppong Raymond, Kigozi Jesse, Chudyk Adrian   +15 more
doaj   +1 more source

Crude incidence in two-phase designs in the presence of competing risks. [PDF]

, 2016
BackgroundIn many studies, some information might not be available for the whole cohort, some covariates, or even the outcome, might be ascertained in selected subsamples. These studies are part of a broad category termed two-phase studies.
A Demnati, AA Tsiatis, AJ Scott, B Langholz, B Langholz, C Särndal, CE Frangakis, David V. Glidden, DG Horvitz, DV Glidden, DY Lin, DY Lin, E Geng, E Marubini, EH Geng, GA Satten, GL Anderson, J Benichou, J Neyman, JP Fine, KE Rudolph, KE Rudolph, Laura Antolini, LC de Wreede, LP Fried, M Wolkewitz, Maria Grazia Valsecchi, N Breslow, NE Breslow, NE Breslow, NP Jewell, OO Aalen, OO Aalen, Paola Rebora, R Core Team, R Franca, RJ Gray, RL Prentice, S Kang, S Kovalchik, SO Samuelsen, T Lumley, TS Lumley, W Barlow, Ø Borgan, Ø Borgan   +45 more
core   +3 more sources

Speciation Through the Lens of Population Dynamics: A Theoretical Primer on How Small and Large Populations Diverge

Population Ecology, EarlyView.
Population size and dynamics fundamentally shape speciation by influencing genetic drift, founder events, and adaptive potential. Small populations may speciate rapidly due to stronger drift, whereas large populations harbor more genetic diversity, which can alter divergence trajectories. We highlight theoretical models that incorporate population size
Ryo Yamaguchi, Hidaka Kubo, Tokuya Ogawa, Hayate Omura   +3 more
wiley   +1 more source

Patients’ and physiotherapists’ perspectives on implementing a tailored stratified treatment approach for low back pain in Nigeria: a qualitative study

BMJ Open, 2022
Background Stratified care has the potential to be efficient in addressing the physical and psychosocial components of low back pain (LBP) and optimise treatment outcomes essential in low-income countries.
Kay Stevenson, Mishael Adje, Jost Steinhäuser, Chidozie Emmanuel Mbada, Sven Karstens   +4 more
doaj   +1 more source

A population-based study on myelodysplastic syndromes in the Lazio Region (Italy), medical miscoding and 11-year mortality follow-up. The Gruppo Romano-Laziale Mielodisplasie experience of retrospective multicentric registry [PDF]

, 2017
Data on Myelodysplastic Syndromes (MDS) are difficult to collect by cancer registries because of the lack of reporting and the use of different classifications of the disease.
Agabiti, Nera, Aloe Spiriti, Maria Antonietta, Andriani, Alessandro, Breccia, Massimo, Buccisano, Francesco, Cimino, Giuseppe, Criscuolo, Marianna, Davoli, Marina, De Fabritiis, Paolo, Faglioni, Laura, Fenu, Susanna, Fianchi, Luana, Gumenyuk, Svitlana, Latagliata, Roberto, Mancini, Stefano, Maurillo, Luca, Mayer, Flavia, Niscola, Pasquale, Nobile, Carolina, Piccioni, Anna Lina, Ricci, Roberto, Tafuri, Agostino, Tatarelli, Caterina, Trapã, Giulio, Voso, Maria Teresa, Zini, Gina   +25 more
core   +2 more sources

Recommendations of the Colombian Consensus Committee for the Management of Traumatic Brain Injury in Prehospital, Emergency Department, Surgery, and Intensive Care (Beyond One Option for Treatment of Traumatic Brain Injury: A Stratified Protocol [BOOTStraP])

Journal of Neurosciences in Rural Practice, 2020
Background Traumatic brain injury (TBI) is a global public health problem. In Colombia, it is estimated that 70% of deaths from violence and 90% of deaths from road traffic accidents are TBI related.
A. Rubiano, D. S. Vera, J. Montenegro, N. Carney, Angelica Clavijo, J. Carreño, O. Gutiérrez, J. Mejía, J. Ciro, Ninel D. Barrios, Alvaro R. Soto, P. Tejada, M. Zerpa, A. Gómez, Norberto Navarrete, Oscar Echeverry, M. Umaña, C. Restrepo, J. Castillo, Oscar A. Sanabria, M. P. Bravo, C. Gómez, D. Godoy, German D. Orjuela, A. A. Arias, Raul A. Echeverri, Jorge Paranos   +26 more
semanticscholar   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Is the apparently protective effect of maternal nicotine replacement therapy (NRT) used in pregnancy on infant development explained by smoking cessation?: secondary analyses of a randomised controlled trial

BMJ Open, 2019
Objective To investigate relationships between maternal smoking status in pregnancy and infant development. The largest randomised controlled trial of nicotine replacement therapy (NRT) for smoking cessation in pregnancy, the smoking, nicotine and ...
Sarah Lewis, Tim Coleman, Barbara Iyen, Luis R Vaz, Jaspal Taggar, Sue Cooper   +5 more
doaj   +1 more source

Risk-stratified and stepped models of care for back pain and osteoarthritis: are we heading towards a common model?

PAIN Reports, 2020
Supplemental Digital Content is Available in the Text. Substantial overlap between interventions and models of care for osteoarthritis and low back pain suggests potential for one common model, which may facilitate implementation.
A. Kongsted, P. Kent, J. Quicke, S. T. Skou, Jonathan C Hill   +4 more
semanticscholar   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source