Results 81 to 90 of about 532,019 (236)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

The comorbidity burden of type 2 diabetes mellitus: patterns, clusters and predictions from a large English primary care cohort

BMC Medicine, 2019
Background The presence of additional chronic conditions has a significant impact on the treatment and management of type 2 diabetes (T2DM). Little is known about the patterns of comorbidities in this population.
Magdalena Nowakowska, Salwa S. Zghebi, Darren M. Ashcroft, Iain Buchan, Carolyn Chew-Graham, Tim Holt, Christian Mallen, Harm Van Marwijk, Niels Peek, Rafael Perera-Salazar, David Reeves, Martin K. Rutter, Stephen F. Weng, Nadeem Qureshi, Mamas A. Mamas, Evangelos Kontopantelis   +15 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Linkage to care within 30 days, stratified by baseline participant characteristics.

, 2022
Linkage to care within 30 days, stratified by baseline participant characteristics.
Gabriel Chamie (310924), Laura B. Balzer (8308602), Erick Wafula Mugoma (14070410), Moses R. Kamya (8308617), Elijah Kakande (3337065), Diane V. Havlir (8374815), Jane Kabami (310926), Norton Sang (5452085), Matthew D. Hickey (6087059), Asiphas Owaraganise (833432), James Ayieko (3168525), Fredrick J. Opel (11457911), Maya L. Petersen (310929)   +12 more
core   +1 more source

Cardiovascular disease morbidity is associated with social deprivation in subjects with familial hypercholesterolaemia (FH): a study comparing FH individuals in UK primary care and the UK Simon Broome register linked with secondary care records

Atherosclerosis Plus, 2022
B. Iyen, N. Qureshi, P. Roderick, N. Capps, P.N. Durrington, I.F.W. McDowell, J. Cegla, H. Soran, J. Schofield, H.A.W. Neil, J. Kai, S. Weng, S.E. Humphries   +12 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Stratified exercise therapy compared with usual care by physical therapists in patients with knee osteoarthritis:A randomized controlled trial protocol (OCTOPuS study) [PDF]

, 2019
Objectives: Knee osteoarthritis (OA) is characterized by its heterogeneity, with large differences in clinical characteristics between patients. Therefore, a stratified approach to exercise therapy, whereby patients are allocated to homogeneous subgroups
Vliet Vlieland, Thea P.M., de Rooij, Mariëtte, van Bodegom-Vos, L, Leti van Bodegom‐Vos, Bennell, KL, Lopuhäa, N., Ostelo, Raymond W.J.G.; id_orcid, Knoop, J., Peter, W.F.H., Ostelo, Raymond W. J. G., Kim L. Bennell, Ostelo, Raymond W.J.G., Knoop, J, Lems, Willem F., van Dongen, Johanna M., Lopuh?a, N., Peter, Wilfred F.H., van Bodegom-Vos, Leti, Peter, WFH, Peter, W.F., van der Esch, M, Johanna M. van Dongen, Vlieland, T.P.M.V., van der Leeden, Marike, Raymond W.J.G. Ostelo, Mariëtte de Rooij, Leeden, M van der, Jesper Knoop, Vliet Vlieland, Thea P. M., Knoop, Jesper; id_orcid, Ostelo, R.W.J.G., Leeden, M. van der, Ostelo, RWJG, Dekker, J., Dongen, J.M. van, Lems, W.F., van der Leeden, M, Dekker, Joost, van der Esch, Martin, Esch, M. van der, Marike van der Leeden, Lopuhäa, N, de Rooij, M, Willem F. Lems, Joost Dekker, Wilfred F.H. Peter, Thea P.M. Vliet Vlieland, Lems, WF, Lopuhäa, Nique, Vliet Vlieland, TPM, Bodegom-Vos, L. van, Martin van der Esch, Rooij, M. de, Bennell, Kim L., Dekker, J, Nique Lopuhäa, Knoop, Jesper, van Dongen, Johanna M, Bennell, K.L., van Dongen, JM, Peter, Wilfred F. H., van Dongen, Johanna M.; id_orcid, Vliet Vlieland, T.P.   +62 more
core   +1 more source

Reduction in cardiovascular disease morbidity of men and women with familial hypercholesterolaemia (FH) associated with availability of high intensity statins: A cohort study using data from the UK Simon Broome Register linked with secondary care records

Atherosclerosis Plus, 2021
B. Iyen, N. Qureshi, P. Roderick, N. Capps, P.N. Durrington, I.F.W. McDowell, J. Cegla, H. Soran, J. Schofield, H.A.W. Neil, J. Kai, S. Weng, S.E. Humphries   +12 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source