Results 81 to 90 of about 11,611 (266)
Cross-provincial inpatient mobility patterns and their determinants in China
BMC Health Services ResearchBackground The incongruity between the regional supply and demand of healthcare services is a persistent challenge both globally and in China. Patient mobility plays a pivotal role in addressing this issue.
Jintao Yang +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Conjugate flows and amplitude bounds for internal solitary waves [PDF]
Nonlinear Processes in Geophysics, 2009 Amplitude bounds imposed by the conservation of mass, momentum and energy for strongly nonlinear waves in stratified fluid are considered. We discuss the theoretical scheme which allows to determine broadening limits for solitary waves in the terms of a ...
N. I. Makarenko +2 more
doaj
A first-principle mechanism for particulate aggregation and self-assembly in stratified fluids
Nature Communications, 2019 Aggregation of matter, common in stratified fluid systems, is essential to the carbon cycle and ocean ecology. Although the current understanding of aggregation involves only collision and adhesion, here Camassa et al.
Roberto Camassa +4 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
A quasi-normal scale elimination model of turbulence and its application to stably stratified flows [PDF]
Nonlinear Processes in Geophysics, 2006 Models of planetary, atmospheric and oceanic circulation involve eddy viscosity and eddy diffusivity, KM and KH, that account for unresolved turbulent mixing and diffusion.
S. Sukoriansky, B. Galperin, V. Perov
doaj
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source