Results 121 to 130 of about 265,026 (252)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Mapping forest aboveground carbon stock of combined stratified sampling and RFRK model with mean annual temperature and precipitation. [PDF]

Sci Rep
Peng M, Xu M, Zhang J, Qiu B, Teng C, Chen C.   +5 more
europepmc   +1 more source

A log rank type test in observational survival studies with stratified sampling. [PDF]

Lifetime Data Anal, 2016
Bai X, Tsiatis AA.
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Evidence of Fine-Scale Genetic Structure in Tiger Sharks (<i>Galeocerdo cuvier</i>) Highlights the Importance of Stratified Sampling Regimes. [PDF]

Evol Appl
Fish JJ, Dudgeon C, Barnett A, Butcher PA, Holmes BJ, Huveneers C, Meyer L, Vigliola L, Sherman CDH, Miller AD.   +9 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A new ensemble learning method stratified sampling blending optimizes conventional blending and improves prediction performance. [PDF]

Bioinform Adv
Miao N, Yang M, Han P, Qiao J, Che Z, Xu F, Dai X, Zhu M.   +7 more
europepmc   +1 more source

Knowledge, attitudes, and perceptions of autism spectrum disorder in a stratified sampling of preschool teachers in China. [PDF]

BMC Psychiatry, 2016
Liu Y, Li J, Zheng Q, Zaroff CM, Hall BJ, Li X, Hao Y.   +6 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Optimizing population mean estimation in stratified sampling using linear cost: A simulation study. [PDF]

Heliyon
Singh P, Sharma P, Singh R, Aloraini B, Akhtar A.   +4 more
europepmc   +1 more source