Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Vibration and Stray Flux Signal Fusion for Corrosion Damage Detection in Rolling Bearings Using Ensemble Learning Algorithms. [PDF]
Sensors (Basel)Pacheco-Guerrero JP +3 more
europepmc +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Development of a Concentrating Optics System for a Photoelectrochemical Hydrogen Reactor
SolarPACES Conference ProceedingsGreen hydrogen is expected to play a crucial role in achieving net-zero carbon emissions. By supporting the development of photoelectrochemical (PEC) hydrogen production, the technology’s advantages in terms of scalability, low-cost materials, and ...
Arend Moelich +4 more
doaj
Rabies Post Exposure Vaccine Effectiveness: A Retrospective Case-Control Study in Amhara Region, Ethiopia. [PDF]
Scientifica (Cairo)Bahiru A +10 more
europepmc +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Editorial: The growing problem of free-roaming dogs: a one health perspective on public and animal health. [PDF]
Front Vet SciViozzi G, Flores V, Sánchez Thevenet P.
europepmc +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Nationwide herd-level seroprevalence of <i>Neospora caninum</i> in dairy herds in Türkiye based on bulk tank milk ELISA and identification of associated risk factors. [PDF]
Front Vet SciErez MS +3 more
europepmc +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source